新木质素属植物综述:分离方法及生物活性。

IF 3.3 3区医学 Q2 CHEMISTRY, MEDICINAL Mini reviews in medicinal chemistry Pub Date : 2017-05-01 DOI:10.2174/1389557516666161130094826

A. Macedo, Thais Carvalho Costa Dos Santos, A. Valverde, D. Moreira, T. Vasconcelos

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引用次数: 10

摘要

背景胡椒属植物以莽草酸途径为主表达，生物合成多种肉桂酸衍生物(CAD)。目的木质素是一类重要的CAD，具有抗菌、抗肿瘤、杀虫、抗炎、抗氧化、平滑肌松弛、神经保护、抗原虫和抗血小板聚集因子等药理作用。这些物质已通过不同的工艺从胡椒属植物中提取和分离。结果综述了1968年至2016年1月期间不同类型新木脂属植物的提取分离方法及生物活性。

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An Overview of Neolignans of the Genus Piper L.: Isolation Methods and Biological Activities.

BACKGROUND The genus Piper L. has the shikimic acid pathway predominantly expressed, biosynthesizing many cinnamic acid derivatives (CAD). OBJECTIVE Neolignans comprise an important class of CAD that exhibit a wide range of pharmacological properties such as antibacterial, antitumor, insecticidal, anti-inflammatory, antioxidant, smooth muscle relaxant, neuroprotective, antiprotozoal and against platelet aggregation factor. These substances have been extracted and isolated from Piper species using different technics. RESULTS The present review aims to summarize extraction and isolation methods and biological activities of the different types of neolignans covering the period from 1968 to January 2016.

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来源期刊

Mini reviews in medicinal chemistry 医学-医药化学

CiteScore

7.80

自引率

0.00%

发文量

231

审稿时长

6 months

期刊介绍： The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines. Mini-Reviews in Medicinal Chemistry covers all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.