白檀和芒果叶提取物对雄性白化Wistar大鼠血清总蛋白、白蛋白和球蛋白急性毒性的影响

N. E. Essien, P. M. Bobson, U. Essien, I. J. Archibong, J. O. Effiong
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引用次数: 0

摘要

研究了重金属急性暴露对白化雄性Wistar大鼠血清总蛋白(TP)、白蛋白(AL)和球蛋白(GL)的影响。25只动物(125 ~ 250 g),随机分为5组,每组5只大鼠。1 ~ 4组在用植物提取物治疗前,连续3次口服低于其LD50的氯化镉(30%)(267 mg/kg),每次间隔2天。第1组和第2组分别以300 mg/kg的剂量处理邦文绥螨和籼稻粉虱。第3组按50:50的剂量比给予两种植物的联合提取物300 mg/kg;第4组和第5组不给予植物提取物,分别作为阳性对照和正常对照。每组动物均可自由使用商品大鼠醪液和水,每天口服治疗两周。实验14 d后,与阳性对照组和正常对照组比较,1组血清中血清素含量显著升高(P0.05)。组2与组5比较,组4显著升高(P0.05)。血清白蛋白水平较4、5组显著升高(P0.05)。与4、5组比较,2组明显降低(P0.05)。第2组与第5组比较差异有统计学意义(P0.05)。这些结果的含义是,人类不应该暴露于重金属中毒,如果暴露,所使用的提取物可以改善。
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Evaluation of Acute Effects of Cadmium Toxicity on Serum Total Protein, Albumin and Globulin in Male Albino Wistar Rats Treated with Ethanol leaf Extracts of Tapinanthus bangwensis and Mangifera indica
Acute impacts of heavy metal exposure on serum total protein (TP), albumin (AL) and globulin (GL) in male albino Wistar rats treated with ethanol leaf extracts of Tapinanthus bangwensis and Mangifera indica were evaluated. Twenty-five (25) animals (125-250 g) were randomly assigned five groups of five rats each. Groups 1-4 were orally administered with cadmium chloride (30 %) below its LD50, (267 mg/kg) each for three times at 2 days interval before treatment with the plant extracts. Groups 1 and 2 were later treated with 300 mg/kg of T. bangwensis and M. indica respectively. Group 3 was treated with 300 mg/kg combined extracts of the two plants at 50:50 dosage ratio while group 4 and 5 were not treated with the plant extracts and served as positive and normal control respectively. Animals in each group were allowed free access to commercial rat mash and water throughput two weeks of treatment which was done daily via oral route. After the fourteen (14) days experimentation, the results revealed a significant increase (P<0.05) in serum total protein in group 2 and 3 when compared to group 1. No significant difference (P>0.05) was observed in group 1 compared to the positive and normal controls. Group 2 showed significant increase (P<0.05) when compared to groups 3 and 5. Group 3 showed significant increase (P<0.05) when compared to groups 4 and 5, but with no significant difference (P>0.05) in group 4 compared to group 5. Serum albumin level showed significant increase (P<0.05) in group 1 when compared to group 2 and 3, but with no significant difference (P>0.05) compared to groups 4 and 5. Significant decrease in group 2 (P<0.05) when compared to group 4. Group 4 compared to group 5. Significant increase in serum albumin was revealed in group 4 when compared to group 5. Serum globulin recorded significant decrease (P<0.05) in group 1 compared to group 2 and 3, but with no significant difference (P>0.05) compared to group 4 and 5. Group 2 showed significant increase (P<0.05) when compared to groups 4 and 5. Group 3 recorded significant increase (P<0.05) in serum globulin when compared to Group 4, but with no significant difference (P>0.05) compared to group 5. The implications of these results are that human should not be exposed to heavy metals to avid toxicity, also if exposed the extracts used could be administered to ameliorate. 
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