抗凝血剂合成方法的研究

Y. Ren, C. Du
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引用次数: 0

摘要

本文主要从合成方法的角度对现有抗凝血剂进行了综述。它涵盖了传统的抗凝剂,如低分子肝素、华法林,以及新的抗凝剂,如阿加曲班、利伐沙班、阿哌沙班和直接凝血酶抑制剂达比加群酯。展望了以达比加群酯为先导化合物的新型抗凝血剂的发展前景。
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The Research on Synthesis Methods of Anticoagulants
This paper summarizes existing anticoagulants mainly from synthesis methods perspective. It covers traditional anticoagulants such as low molecular weight heparins, warfarin, as well as new anticoagulants like argatroban, rivaroxaban, apixaban and direct thrombin inhibitors dabigatran etexilate. This paper also looks forward to future novel anticoagulants using dabigatran etexilate as a lead compound.
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