A. Kuzikov, A. Veselovsky, I. Toropygin, A. Archakov, V. Shumyantseva
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INTERACTIONS OF ANTICANCER DRUGS – ABIRATERONE AND GALETERONE – WITH CYTOCHROME P450 51A1 (CYP51A1)
Interactions of abiraterone and galeterone with steroid-metabolizing cytochrome P450 (CYP51A1) was studied. Binding of substrate type was observed, which indicates possible metabolism of abiraterone and galeterone by CYP51A1, however electrocatalytic reaction only towards abiraterone was observed.
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