香豆素类PDE抑制剂的设计与微波辅助合成

International Journal of Medicinal Chemistry Pub Date : 2016-02-21 DOI:10.1155/2016/9890630

M. Kumbar, R. Kamble, A. Kamble, S. R. Salian, S. Kumari, Ramya Nair, G. Kalthur, S. Adiga, D. J. Prasad

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引用次数: 10

摘要

采用微波辐照法，通过吡唑对苯并咪唑进行了香豆素的设计与合成。通过精子运动模式间接分析了这些化合物对磷酸二酯酶(PDE)的抑制作用。合成的部分化合物5d、5e、5f、5g、5h、5k对PDE表现出较强的抑制活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Design and Microwave Assisted Synthesis of Coumarin Derivatives as PDE Inhibitors

Coumarins appended to benzimidazole through pyrazole are designed and synthesized using microwave irradiation. These compounds were analyzed for phosphodiesterase (PDE) inhibition indirectly by motility pattern in human spermatozoa. Some of the synthesized compounds, namely, 5d, 5e, 5f, 5g, 5h, and 5k, have exhibited potent inhibitory activity on PDE.

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International Journal of Medicinal Chemistry CHEMISTRY, MEDICINAL-

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期刊介绍： International Journal of Medicinal Chemistry is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of chemistry associated with drug discovery, design, and synthesis. International Journal of Medicinal Chemistry is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of chemistry associated with drug discovery, design, and synthesis.