生殖期妄想障碍:更年期对临床病程的潜在影响

IF 3.6 Q1 PSYCHIATRY Schizophrenia Research and Treatment Pub Date : 2015-10-27 DOI:10.1155/2015/979605
A. González-Rodríguez, O. Molina-Andreu, R. Penadés, M. Garriga, A. Pons, R. Catalán, M. Bernardo
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引用次数: 12

摘要

背景和目标。最近的证据支持雌激素水平与精神分裂症妇女精神病理严重程度之间的关联。我们的主要目的是调查绝经前和绝经后发病的妄想障碍(DD)妇女在人口统计学和临床特征上是否存在差异。方法。在基线、6个月和24个月后对80名DD妇女的精神病理症状进行评估(DSM-IV-TR)。PANSS、功能性PSP、HRSD 17项、自杀C-SSRS和SUMD的得分被认为是结果变量。为了进行比较,进行了t检验和χ 2检验,必要时进行了非参数检验。采用协方差分析(ANCOVA)进行多变量比较。结果:80名DD女性中有57人完成了研究。未经调整时,绝经前发病的DD患者DUP时间较长,受教育程度较高,妇科疾病发生率较高。色欲型在绝经前发病的DD妇女中最常见,而躯体型和嫉妒型在绝经后发病的DD妇女中最常见。24个月后,绝经前发病的DD妇女表现出更高的抑郁症状和精神病复发的倾向。结论。我们的研究结果支持,精神病理学和洞察力的某些方面可能会根据DD的发病和生殖状态而有所不同。
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Delusional Disorder over the Reproductive Life Span: The Potential Influence of Menopause on the Clinical Course
Background and Objectives. Recent evidence supports an association between estrogen levels and severity of psychopathology in schizophrenia women. Our main goal was to investigate whether delusional disorder (DD) women with premenopausal onset and those with postmenopausal onset differ in demographic and clinical features. Methods. Psychopathological symptoms were assessed in 80 DD women (DSM-IV-TR), at baseline and after six and 24 months. Scores in the PANSS, PSP for functionality, HRSD 17 items, C-SSRS for suicide, and the SUMD were considered outcome variables. For comparison purposes, t- and χ 2-tests were performed and nonparametric tests when necessary. Analysis of Covariance (ANCOVA) was conducted for multivariate comparisons. Results. 57 out of 80 DD women completed the study. When unadjusted, DD with premenopausal onset had a longer DUP, higher educational level, and a tendency toward higher rates of gynaecological disorders. Erotomanic type was most frequent in DD women premenopausal onset, and somatic and jealous types were most frequent in those with postmenopausal onset. After 24 months, DD women with premenopausal onset showed higher depressive symptoms and a tendency toward higher rates of psychotic relapses. Conclusions. Our results support that some aspects of psychopathology and insight may differ according to the onset of DD and the reproductive status.
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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
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