玉米丝原提取物的药理研究

O. Naboka, L. Vyshnevska, Inna Pasynchuk, O. Filiptsova, O. Tkachenko, Olha Vislous
{"title":"玉米丝原提取物的药理研究","authors":"O. Naboka, L. Vyshnevska, Inna Pasynchuk, O. Filiptsova, O. Tkachenko, Olha Vislous","doi":"10.15587/2519-8025.2022.271049","DOIUrl":null,"url":null,"abstract":"Aim: the aim of the research is a pharmacological study of the original extracts of corn silk.\nMaterials and methods. The object of the study were 4 original extracts of corn silk, obtained by extraction with water and ethanol of different concentrations, namely: aqueous extract of corn silk (ACSE), extract of corn silk, extracted with ethanol 30 % (ECSE 30 %) , extract of corn silk, extracted with ethanol 50 % (ЕCSЕ 50 %), extract of corn silk, extracted with ethanol 70 % (ЕCSЕ 70 %). A screening study of the antioxidant properties of corn silk extracts was carried out in vitro using models of spontaneous and ascorbate-induced lipid peroxidation (LPO) in rat liver homogenate.\nResults. As can be seen from the given data, ECSE 50 % at a dose of 20 mg/kg showed a pronounced protective effect on the hepatotoxicity of TСM. Its use led to a probable restoration of the bile-forming function of the liver against the background of tetrachloromethane hepatitis: in response to an increase in the cholesterol content (by 43 %, p<0.05), the content of bile acids increased 2 times (p<0.05), as a result of which cholate -cholesterol ratio approached the level of indicators of intact animals, the rate of bile secretion normalized. Based on the analysis of the results of the study, it can be concluded, that in terms of bile-forming and choleretic activity on the tetrachloromethane hepatitis model, ECSE 50 % was not inferior to silibor and superior to quercetin (р<0.05).\nConclusions. Biologically active substances of corn silk affect not only the diffusion and filtration processes of the liver parenchyma, but also the biosynthesis and transport of its organic components, that is, they affect the bile-forming function","PeriodicalId":21636,"journal":{"name":"ScienceRise: Biological Science","volume":"27 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pharmacological study of original extracts of corn silk\",\"authors\":\"O. Naboka, L. Vyshnevska, Inna Pasynchuk, O. Filiptsova, O. Tkachenko, Olha Vislous\",\"doi\":\"10.15587/2519-8025.2022.271049\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Aim: the aim of the research is a pharmacological study of the original extracts of corn silk.\\nMaterials and methods. The object of the study were 4 original extracts of corn silk, obtained by extraction with water and ethanol of different concentrations, namely: aqueous extract of corn silk (ACSE), extract of corn silk, extracted with ethanol 30 % (ECSE 30 %) , extract of corn silk, extracted with ethanol 50 % (ЕCSЕ 50 %), extract of corn silk, extracted with ethanol 70 % (ЕCSЕ 70 %). A screening study of the antioxidant properties of corn silk extracts was carried out in vitro using models of spontaneous and ascorbate-induced lipid peroxidation (LPO) in rat liver homogenate.\\nResults. As can be seen from the given data, ECSE 50 % at a dose of 20 mg/kg showed a pronounced protective effect on the hepatotoxicity of TСM. Its use led to a probable restoration of the bile-forming function of the liver against the background of tetrachloromethane hepatitis: in response to an increase in the cholesterol content (by 43 %, p<0.05), the content of bile acids increased 2 times (p<0.05), as a result of which cholate -cholesterol ratio approached the level of indicators of intact animals, the rate of bile secretion normalized. Based on the analysis of the results of the study, it can be concluded, that in terms of bile-forming and choleretic activity on the tetrachloromethane hepatitis model, ECSE 50 % was not inferior to silibor and superior to quercetin (р<0.05).\\nConclusions. Biologically active substances of corn silk affect not only the diffusion and filtration processes of the liver parenchyma, but also the biosynthesis and transport of its organic components, that is, they affect the bile-forming function\",\"PeriodicalId\":21636,\"journal\":{\"name\":\"ScienceRise: Biological Science\",\"volume\":\"27 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-12-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ScienceRise: Biological Science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15587/2519-8025.2022.271049\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ScienceRise: Biological Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15587/2519-8025.2022.271049","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

目的:对玉米蚕丝原提取物进行药理研究。材料和方法。以不同浓度的水和乙醇提取得到的4种原玉米丝提取物为研究对象,分别为:玉米丝水提物(ACSE)、玉米丝乙醇提物(ECSE 30%)、玉米丝乙醇提物(ЕCSЕ 50%)、玉米丝乙醇提物(ЕCSЕ 70%)。采用抗坏血酸诱导的大鼠肝脏自发脂质过氧化和抗坏血酸诱导的脂质过氧化(LPO)模型,对玉米丝提取物的抗氧化性能进行了体外筛选研究。从给定的数据可以看出,50%的ECSE在20 mg/kg的剂量下对TСM的肝毒性有明显的保护作用。在四氯甲烷肝炎的背景下,它的使用可能导致肝脏胆汁形成功能的恢复:随着胆固醇含量的增加(43%,p<0.05),胆汁酸含量增加2倍(p<0.05),从而使胆胆固醇比接近正常动物的指标水平,胆汁分泌率恢复正常。通过对研究结果的分析,可以得出结论,在四氯甲烷肝炎模型的胆汁形成和胆汁活性方面,ECSE 50%不逊于silbor,优于槲皮素(p <0.05)。玉米丝的生物活性物质不仅影响肝实质的扩散和过滤过程,而且影响其有机成分的生物合成和运输,即影响胆汁的形成功能
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Pharmacological study of original extracts of corn silk
Aim: the aim of the research is a pharmacological study of the original extracts of corn silk. Materials and methods. The object of the study were 4 original extracts of corn silk, obtained by extraction with water and ethanol of different concentrations, namely: aqueous extract of corn silk (ACSE), extract of corn silk, extracted with ethanol 30 % (ECSE 30 %) , extract of corn silk, extracted with ethanol 50 % (ЕCSЕ 50 %), extract of corn silk, extracted with ethanol 70 % (ЕCSЕ 70 %). A screening study of the antioxidant properties of corn silk extracts was carried out in vitro using models of spontaneous and ascorbate-induced lipid peroxidation (LPO) in rat liver homogenate. Results. As can be seen from the given data, ECSE 50 % at a dose of 20 mg/kg showed a pronounced protective effect on the hepatotoxicity of TСM. Its use led to a probable restoration of the bile-forming function of the liver against the background of tetrachloromethane hepatitis: in response to an increase in the cholesterol content (by 43 %, p<0.05), the content of bile acids increased 2 times (p<0.05), as a result of which cholate -cholesterol ratio approached the level of indicators of intact animals, the rate of bile secretion normalized. Based on the analysis of the results of the study, it can be concluded, that in terms of bile-forming and choleretic activity on the tetrachloromethane hepatitis model, ECSE 50 % was not inferior to silibor and superior to quercetin (р<0.05). Conclusions. Biologically active substances of corn silk affect not only the diffusion and filtration processes of the liver parenchyma, but also the biosynthesis and transport of its organic components, that is, they affect the bile-forming function
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
8
审稿时长
6 weeks
期刊最新文献
Vitamin A accelerates the process of liver regeneration in the initial stages of Сu - induced fibrosis Effectiveness of environmentally safe products «VetOks-1000», «Sumerian silver» for the prevention of pseudomonosis of poultry embryos associated with bacteriosis Modulation of mesenchymal stromal cells properties by the microenvironment in 3D culture Dietary preferences and analysis of the "plant-based food basket" among Ukrainian preteens and teenagers The influence of agricultural land on the level of airborne Alternaria spores
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1