高血糖会改变胸腺上皮细胞的功能

Journal of Medical Hypotheses and Ideas Pub Date : 2013-07-01 DOI:10.1016/j.jmhi.2013.04.001

Vera Alexandrovna Abramova, Nikolai Nikolaevich Belyaev

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引用次数: 0

摘要

胰岛素依赖型糖尿病(IDDM)被认为是不受控制的自身免疫过程的结果。免疫系统反应的改变被认为是该疾病的原因，但代谢物水平(葡萄糖)的改变是否可能通过特异性作用于胸腺基质功能并改变胸腺基质功能而导致疾病的发生，目前尚未研究。因此，高血糖作为一种致病因子对中枢耐受机制的直接影响需要进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Hyperglycaemia alters thymic epithelial cell function

Insulin-dependent diabetes mellitus (IDDM) is considered to be a consequence of unchecked auto-immune processes. Alterations in immune system responses are thought to be the cause of the disease, but the possibility that altered metabolite levels (glucose) can establish the disease by specifically acting on and altering thymus stroma functions has not been investigated. Therefore, the direct effect of hyperglycaemia (HG) on central tolerance mechanisms as a causative agent needs to be investigated.

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