两种商业黑皮籽油的生物学、植物化学和物理化学性质:比较分析

M. Z. Aumeeruddy, Z. Aumeeruddy-Elalfi, H. Neetoo, G. Zengin, B. Fibrich, S. Rademan, A. B. V. Staden, K. Szuman, I. Lambrechts, N. Lall, M. Mahomoodally
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引用次数: 3

摘要

本研究旨在评价和比较两种NSS (Nigella sativa seed)油(N1和N2)的生物学、植物化学和理化性质。从抗菌、抗氧化(清除一氧化氮)、抗弹性酶、抗酪氨酸酶、抗黑色素瘤和抗癌活性等方面对其生物活性进行了评价。理化性质包括颜色、总可溶性固形物(TSS)和密度也进行了研究。N2对HeLa细胞株具有较高的抗菌、NO清除、细胞外抗黑素生成和抗癌活性,而N1具有较高的抗酪氨酸酶活性。N1处理的总酚含量(TPC)和总黄酮含量(TFC)显著高于N2处理,总单宁含量(TTC)显著高于N2处理。事实上,TTC与抗氧化、细胞外抗黑素生成和HeLa细胞抑制活性密切相关(R=1.000)。综上所述,NSS油可能被认为是治疗感染性和慢性疾病的补充和替代疗法,但需要进一步的体内药理验证和毒理学分析。
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Biological, phytochemical, and physico-chemical properties of two commercial Nigella sativa seed oils: A comparative analysis
This study was designed to evaluate and correlate the biological, phytochemical, and physicochemical properties of two NSS (Nigella sativa seed) oils (N1 and N2). The biological activity was evaluated in terms of antibacterial, antioxidant (nitric oxide scavenging), antielastase, antityrosinase, antimelanogenic, and anticancer activity. Physicochemical properties including colour, total soluble solids (TSS), and density were also investigated. N2 exhibited higher antibacterial, NO scavenging, extracellular antimelanogenic, and anticancer activity against the HeLa cell line compared to N1, which showed higher antityrosinase activity. TPC (total phenolic content) and TFC (total flavonoid content) of N1 were significantly higher than N2 while TTC (total tannin content) was higher in N2. In fact, TTC was strongly correlated (R=1.000) with the antioxidant, extracellular antimelanogenic, and HeLa cell inhibitory activity. To conclude, NSS oil may be considered as a complementary and alternative therapy in the management of infectious and chronic diseases but warrants further in vivo pharmacological validation and toxicological analysis.
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