两种商业黑皮籽油的生物学、植物化学和物理化学性质:比较分析

M. Z. Aumeeruddy, Z. Aumeeruddy-Elalfi, H. Neetoo, G. Zengin, B. Fibrich, S. Rademan, A. B. V. Staden, K. Szuman, I. Lambrechts, N. Lall, M. Mahomoodally
{"title":"两种商业黑皮籽油的生物学、植物化学和物理化学性质:比较分析","authors":"M. Z. Aumeeruddy, Z. Aumeeruddy-Elalfi, H. Neetoo, G. Zengin, B. Fibrich, S. Rademan, A. B. V. Staden, K. Szuman, I. Lambrechts, N. Lall, M. Mahomoodally","doi":"10.26650/ISTANBULJPHARM.2018.180003","DOIUrl":null,"url":null,"abstract":"This study was designed to evaluate and correlate the biological, phytochemical, and physicochemical properties of two NSS (Nigella sativa seed) oils (N1 and N2). The biological activity was evaluated in terms of antibacterial, antioxidant (nitric oxide scavenging), antielastase, antityrosinase, antimelanogenic, and anticancer activity. Physicochemical properties including colour, total soluble solids (TSS), and density were also investigated. N2 exhibited higher antibacterial, NO scavenging, extracellular antimelanogenic, and anticancer activity against the HeLa cell line compared to N1, which showed higher antityrosinase activity. TPC (total phenolic content) and TFC (total flavonoid content) of N1 were significantly higher than N2 while TTC (total tannin content) was higher in N2. In fact, TTC was strongly correlated (R=1.000) with the antioxidant, extracellular antimelanogenic, and HeLa cell inhibitory activity. To conclude, NSS oil may be considered as a complementary and alternative therapy in the management of infectious and chronic diseases but warrants further in vivo pharmacological validation and toxicological analysis.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Biological, phytochemical, and physico-chemical properties of two commercial Nigella sativa seed oils: A comparative analysis\",\"authors\":\"M. Z. Aumeeruddy, Z. Aumeeruddy-Elalfi, H. Neetoo, G. Zengin, B. Fibrich, S. Rademan, A. B. V. Staden, K. Szuman, I. Lambrechts, N. Lall, M. Mahomoodally\",\"doi\":\"10.26650/ISTANBULJPHARM.2018.180003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This study was designed to evaluate and correlate the biological, phytochemical, and physicochemical properties of two NSS (Nigella sativa seed) oils (N1 and N2). The biological activity was evaluated in terms of antibacterial, antioxidant (nitric oxide scavenging), antielastase, antityrosinase, antimelanogenic, and anticancer activity. Physicochemical properties including colour, total soluble solids (TSS), and density were also investigated. N2 exhibited higher antibacterial, NO scavenging, extracellular antimelanogenic, and anticancer activity against the HeLa cell line compared to N1, which showed higher antityrosinase activity. TPC (total phenolic content) and TFC (total flavonoid content) of N1 were significantly higher than N2 while TTC (total tannin content) was higher in N2. In fact, TTC was strongly correlated (R=1.000) with the antioxidant, extracellular antimelanogenic, and HeLa cell inhibitory activity. To conclude, NSS oil may be considered as a complementary and alternative therapy in the management of infectious and chronic diseases but warrants further in vivo pharmacological validation and toxicological analysis.\",\"PeriodicalId\":14484,\"journal\":{\"name\":\"İstanbul Journal of Pharmacy\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-10-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"İstanbul Journal of Pharmacy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.26650/ISTANBULJPHARM.2018.180003\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"İstanbul Journal of Pharmacy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.26650/ISTANBULJPHARM.2018.180003","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3

摘要

本研究旨在评价和比较两种NSS (Nigella sativa seed)油(N1和N2)的生物学、植物化学和理化性质。从抗菌、抗氧化(清除一氧化氮)、抗弹性酶、抗酪氨酸酶、抗黑色素瘤和抗癌活性等方面对其生物活性进行了评价。理化性质包括颜色、总可溶性固形物(TSS)和密度也进行了研究。N2对HeLa细胞株具有较高的抗菌、NO清除、细胞外抗黑素生成和抗癌活性,而N1具有较高的抗酪氨酸酶活性。N1处理的总酚含量(TPC)和总黄酮含量(TFC)显著高于N2处理,总单宁含量(TTC)显著高于N2处理。事实上,TTC与抗氧化、细胞外抗黑素生成和HeLa细胞抑制活性密切相关(R=1.000)。综上所述,NSS油可能被认为是治疗感染性和慢性疾病的补充和替代疗法,但需要进一步的体内药理验证和毒理学分析。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Biological, phytochemical, and physico-chemical properties of two commercial Nigella sativa seed oils: A comparative analysis
This study was designed to evaluate and correlate the biological, phytochemical, and physicochemical properties of two NSS (Nigella sativa seed) oils (N1 and N2). The biological activity was evaluated in terms of antibacterial, antioxidant (nitric oxide scavenging), antielastase, antityrosinase, antimelanogenic, and anticancer activity. Physicochemical properties including colour, total soluble solids (TSS), and density were also investigated. N2 exhibited higher antibacterial, NO scavenging, extracellular antimelanogenic, and anticancer activity against the HeLa cell line compared to N1, which showed higher antityrosinase activity. TPC (total phenolic content) and TFC (total flavonoid content) of N1 were significantly higher than N2 while TTC (total tannin content) was higher in N2. In fact, TTC was strongly correlated (R=1.000) with the antioxidant, extracellular antimelanogenic, and HeLa cell inhibitory activity. To conclude, NSS oil may be considered as a complementary and alternative therapy in the management of infectious and chronic diseases but warrants further in vivo pharmacological validation and toxicological analysis.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Ameliorative effect of cranberry on erectile function in diabetic rats Inhibitory potentials of Moringa oleifera on activities of neuraminidase, xanthine oxidase and adenosine deaminase A chemometrics-based approach for the determination of thymoquinone from Nigella sativa L. (Black Cumin) seeds of different geographical regions using the HPLC technique Virtual drug screening for p65/rela subunit of nf-κb: Promising repurposable drugs in the treatment of stress-based diseases Taxonomic significance of anatomy and achene micromorphology of selected Cousinia Cass. species (Asteraceae)
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1