Lina Nguyen, Ethan-Quan Nguyen, Cassandra Tran, K. Nguyen, Ananya Devarajan, K. Berg, H. Hirschberg
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引用次数: 0
摘要
减少术后肿瘤复发和减轻全身化疗副作用的一种方法是通过集中和靶向的外部施加物理能量来开发药物激活,从而提供部位和时间特异性。其中一种技术,光介导的光化学内化(PCI),已被证明是一种获得各种抗癌药物增强化疗效果的方法。一项相关技术,超声化学内在化(SCI),是PCI概念的延伸,旨在克服组织中光线穿透力差的局限性。SCI利用超声波能量,激活声敏剂,与抗癌药物共同施用。本文报道的研究目的是评估博来霉素(BLM)的SCI在体外和体内对乳腺腺癌大鼠肿瘤细胞系Mat B III的抑制作用。在体外研究了BLM的超声作用,即sonoporation (SP)和sonochemical internalization (SCI)。在体内,在Fisher大鼠原位乳腺肿瘤动物模型中,Mat B III植入后,BLM-SCI显著抑制肿瘤的发展。
Sonochemical Internalization of Bleomycin Inhibits Adenocarcinoma Breast Tumor Development in an Orthotopic Rat Model.
One approach to reducing post-operative tumor recurrence and alleviate debilitating side effects of systemic chemotherapy, is work centered on the development of drug activation by focused and targeted externally applied physical energy thus providing site and temporal specificity. One such technique, light mediated photochemical internalization (PCI), has been shown to be a method to obtain enhanced chemotherapy efficacy for a wide variety of anti-cancer agents. A related technology, sonochemical internaization (SCI), is an extension of the PCI concept developed to overcome the limitations of poor light penetration in tissue. SCI utilizes ultrasonic energy, to activate sonosensitizers, co-administered with anti cancer agents. The purpose of the study reported here was to evaluate the inhibitory effects of SCI of bleomycin (BLM), both in vitro and in vivo, on the adenocarcinoma breast tumor rat cell line Mat B III. In vitro, the two aspects of sonication, sonoporation (SP) and sonochemical internalization (SCI) of BLM were examined. In vivo, BLM-SCI significantly inhibited tumor development, following Mat B III implantation, in an orthotopic breast tumor animal model using Fisher rats.