光活性重氮环磷酰胺:一种测定胺和醇绝对构型的新型高效试剂

T. Oshikawa,, M. Yamashita,, Sadaaki Kumagai, K. Seo, J. Kobayashi
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引用次数: 12

摘要

各种胺和醇在具有光学活性的二氮杂环磷酰胺氯化物的作用下转化为相应的磷酰胺,并且通过所形成的环磷酰胺的质子和磷核磁共振很容易确定胺和醇的绝对构型。
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Optically active diazacyclophosphamides: novel efficient reagents for the determination of the absolute configuration of amines and alcohols
Various amines and alcohols are converted into the corresponding phosphamides by the action of optically active diazacyclophosphamidic chlorides and absolute configurations of amines and alcohols are readily determined by proton and phosphorus NMR of the cyclophosphamides that are formed.
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