Protracted effects of caffeine after hemodialysis for severe caffeine intoxication

Abstract Caffeine induces neurological effects at high doses. However, the duration and extent of neurological manifestations with respect to serum theophylline and caffeine concentrations is unknown. A 19-year-old woman suffering from severe caffeine overdose showed signs of neurological effects that persisted for more than 60 h despite hemodialysis and the normalization of caffeine and theophylline concentrations. Although serum theophylline and caffeine concentrations can be used to monitor the effect of severe caffeine overdose, central nervous system toxicity may persist after the concentrations normalize.