紫外线相关皮肤癌易感性的遗传决定因素

Exogenous Dermatology Pub Date : 2004-07-01 DOI:10.1159/000091899

E. Sprecher

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摘要

紫外线照射已被认为是过去几年观察到的皮肤癌发病率稳步上升的原因。然而，个体对紫外线致瘤效应的反应差异很大。在调节对紫外线的反应的许多因素中，遗传变异起着关键作用。本文综述了我们对紫外线诱导皮肤癌发病机制中涉及的主要遗传和非遗传基因修饰的理解的主要进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Genetic Determinants of Susceptibility to UV Light-Associated Skin Cancer

UV light exposure has been incriminated for the steady rise in skin cancer incidence observed during the last years. However, individual responses to the oncogenic effects of UV light are greatly variable. Among the many factors modulating the response to UV light, genetic variations play a pivotal role. This review examines major progress in our understanding of major hereditary and nonhereditary genetic modifiers involved in the pathogenesis of UV-induced skin cancer.

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Exogenous Dermatology

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