{"title":"紫外线相关皮肤癌易感性的遗传决定因素","authors":"E. Sprecher","doi":"10.1159/000091899","DOIUrl":null,"url":null,"abstract":"UV light exposure has been incriminated for the steady rise in skin cancer incidence observed during the last years. However, individual responses to the oncogenic effects of UV light are greatly variable. Among the many factors modulating the response to UV light, genetic variations play a pivotal role. This review examines major progress in our understanding of major hereditary and nonhereditary genetic modifiers involved in the pathogenesis of UV-induced skin cancer.","PeriodicalId":12086,"journal":{"name":"Exogenous Dermatology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2004-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Genetic Determinants of Susceptibility to UV Light-Associated Skin Cancer\",\"authors\":\"E. Sprecher\",\"doi\":\"10.1159/000091899\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"UV light exposure has been incriminated for the steady rise in skin cancer incidence observed during the last years. However, individual responses to the oncogenic effects of UV light are greatly variable. Among the many factors modulating the response to UV light, genetic variations play a pivotal role. This review examines major progress in our understanding of major hereditary and nonhereditary genetic modifiers involved in the pathogenesis of UV-induced skin cancer.\",\"PeriodicalId\":12086,\"journal\":{\"name\":\"Exogenous Dermatology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2004-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Exogenous Dermatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1159/000091899\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Exogenous Dermatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000091899","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Genetic Determinants of Susceptibility to UV Light-Associated Skin Cancer
UV light exposure has been incriminated for the steady rise in skin cancer incidence observed during the last years. However, individual responses to the oncogenic effects of UV light are greatly variable. Among the many factors modulating the response to UV light, genetic variations play a pivotal role. This review examines major progress in our understanding of major hereditary and nonhereditary genetic modifiers involved in the pathogenesis of UV-induced skin cancer.
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