Evaluation of accumulation and tissue effects of biological magnetic iron nanoparticles in response to the electromagnetic field by Inductively Coupled Plasma and histopathological methods in liver tissue of wistar rats

Aim: The aim is to investigate the effects of magnetic nanoparticles on tissue health. Material and Methods : Magnetic iron nanoparticles were produced using Fusarium oxysporum and after proving their size to evaluate their effect on the liver tissue of 24 rats, they were randomly selected and divided into 4 groups. Based on the interventions, nanoparticles were injected intraperitoneally. At the end of the experiment, tissue sampling was performed and the samples were sent to the laboratory to prepare histopathological sections and analyze induced paired plasma spectroscopy. Results: The fungus produced magnetic iron nanoparticles and visible light spectrophotometer tests, X-ray diffraction confirmed its presence and electron microscopy showed that their average size is 20 to 30 nm. MTT test also showed that magnetic iron nanoparticles have low toxicity and ICP analysis showed that with the presence of electromagnetic field, the rate of entry of iron nanoparticles into the tissue has increased. Microscopic results also showed that the most changes in hepatocytes, lobular center vein and sinusoidal space were in the electromagnetic field group and non-toxic dose group of nanoparticles with the presence of electromagnetic field. Conclusion : Based on the results, it can be said that while magnetic iron nanoparticles do not induce a specific toxic effect in tissue, but the probability that the electromagnetic field itself causes tissue changes increases.