无聚合物 Biolimus A9 涂层支架与耐用聚合物 Everolimus 洗脱支架的 1 个月和 12 个月血管反应比较。

IF 1.5 4区 农林科学 Q4 SOIL SCIENCE Canadian Journal of Soil Science Pub Date : 2022-08-25 Epub Date: 2022-06-04 DOI:10.1253/circj.CJ-22-0098
Takayuki Ishihara, Isamu Mizote, Daisuke Nakamura, Naotaka Okamoto, Tatsuya Shiraki, Naoki Itaya, Takuya Tsujimura, Mitsuyoshi Takahara, Takaharu Nakayoshi, Osamu Iida, Yosuke Hata, Masami Nishino, Takafumi Ueno, Daisaku Nakatani, Shungo Hikoso, Shinsuke Nanto, Toshiaki Mano, Yasushi Sakata
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引用次数: 0

摘要

背景:不含聚合物的依维莫司 A9 涂层支架(PF-BCS)因其不含聚合物的特点,可能比耐久性聚合物药物洗脱支架获得更好的动脉愈合效果:这项多中心、前瞻性、观察性研究共纳入 105 名患者(132 个病变),他们分别接受了 PF-BCS(51 名患者,71 个病变)或耐久性聚合物依维莫司洗脱支架(DP-EES,54 名患者,61 个病变)植入术。在1个月和12个月时进行了连续冠状动脉血管造影(CAS)和光学相干断层扫描(OCT)检查,并比较了PF-BCS和DP-EES的连续血管反应。主要结果指标是 CAS 上亚临床隐匿性血栓的发生率。次要结果指标是:OCT上的充分支柱覆盖(≥40 μm)和CAS上的最大黄色分级。血栓发生率在1个月时较高(100% vs. 93%,P=0.091),但在12个月时有所下降(18% vs. 25%,P=0.56),PF-BCS和DP-EES之间无显著差异。适当的支柱覆盖率明显更高(84±14% vs. 69±22%,PC结论:虽然PF-BCS的血栓形成率与DP-EES相似,但在12个月时,PF-BCS的充分覆盖率和斑块稳定率优于DP-EES。
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Comparison of 1-Month and 12-Month Vessel Responses Between the Polymer-Free Biolimus A9-Coated Stent and the Durable Polymer Everolimus-Eluting Stent.

Background: A polymer-free biolimus A9-coated stent (PF-BCS) may achieve better arterial healing than a durable polymer drug-eluting stent owing to its polymer-free feature.

Methods and results: This multicenter, prospective, observational study enrolled 105 patients (132 lesions) who underwent PF-BCS (51 patients, 71 lesions) or durable polymer everolimus-eluting stent (DP-EES, 54 patients, 61 lesions) implantation. Serial coronary angioscopy (CAS) and optical coherence tomography (OCT) examinations were performed at 1 and 12 months, and the serial vessel responses were compared between PF-BCS and DP-EES. The primary outcome measure was the incidence of subclinical intrastent thrombus on CAS. The secondary outcome measures were: adequate strut coverage (≥40 μm) on OCT and maximum yellow color grade on CAS. The incidence of thrombus was high at 1 month (100% vs. 93%, P=0.091), but decreased at 12 months (18% vs. 25%, P=0.56), without a significant difference between PF-BCS and DP-EES. The adequate strut coverage rate was significantly higher (84±14% vs. 69±22%, P<0.001) and yellow color was significantly less intense (P=0.012) at 12 months in PF-BCS than in DP-EES; however, they were not significantly different at 1 month (adequate strut coverage: 47±21% vs. 50±17%, P=0.40; yellow color: P=0.99).

Conclusions: Although the thrombogenicity of PF-BCS was similar to that of DP-EES, the adequate coverage and plaque stabilization rates of PF-BCS were superior to those of DP-EES at 12 months.

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来源期刊
Canadian Journal of Soil Science
Canadian Journal of Soil Science 农林科学-土壤科学
CiteScore
2.90
自引率
11.80%
发文量
73
审稿时长
6.0 months
期刊介绍: The Canadian Journal of Soil Science is an international peer-reviewed journal published in cooperation with the Canadian Society of Soil Science. The journal publishes original research on the use, management, structure and development of soils and draws from the disciplines of soil science, agrometeorology, ecology, agricultural engineering, environmental science, hydrology, forestry, geology, geography and climatology. Research is published in a number of topic sections including: agrometeorology; ecology, biological processes and plant interactions; composition and chemical processes; physical processes and interfaces; genesis, landscape processes and relationships; contamination and environmental stewardship; and management for agricultural, forestry and urban uses.
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