不同多孔支架液体灌注下干细胞体外力学反应的评价

S. Majumder, Abhisek Gupta, Sandeep Choudhury, Amit Roy Chowdhury
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摘要

在骨组织工程中,合适的支架结构是获得良好组织响应的关键。为此,我们对不同多孔支架进行流固耦合分析,观察其在流体流动作用下的体外力学响应,并采用子建模方法获得细胞变形和应变。根据不同的孔隙率和结构设计了不同类型的支架。用细胞质、细胞核、细胞膜和细胞骨架来模拟细胞。该研究的主要目的是研究由于支架的不同孔隙度和结构而引起的细胞反应的变化。研究结果表明,螺旋结构的渗透率较高,金刚石结构的壁剪应力(WSS)较高。各支架的透气性随孔隙率的增加而增加。支架内的WSS则呈现相反的趋势。当细胞朝向流体流动的方向放置在支架的前端位置时,细胞表现出更高的变形。这项研究将指导我们预测更好的细胞生长的理想支架。
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Evaluating the in Vitro Mechanical Responses of Stem Cell Under Fluid Perfusion in Different Porous Scaffolds
A suitable scaffold architecture is always desirable to get a favorable tissue response for bone tissue engineering. In this regard, a fluid-structure interaction analysis was carried out on different porous scaffolds to observe the in vitro mechanical responses due to fluid flow, followed by a submodeling method to obtain the cellular deformation and strain. Different types of scaffolds were designed based on different porosity and architecture. The cell was modelled with cytoplasm, nucleus, cell membrane, and cytoskeletons. The main objective of the study is to examine the variation of cellular responses due to different porosity and architecture of the scaffold. The results of this study highlight that permeability is higher in the case of gyroid structure and wall shear stress (WSS) is higher in the case of diamond structure. The permeability of all scaffolds increases with the increase of porosity. The opposite trend is shown in the case of WSS within scaffolds. The cell is showing higher deformation when it is placed on the front position of the scaffold towards the direction of fluid flow. This study will guide us in predicting an ideal scaffold for better cell growth.
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