生物样品中抗抑郁药测定的前处理技术中当前生物分析方法的综述

IF 3.6 3区 化学 Q2 CHEMISTRY, ANALYTICAL Reviews in Analytical Chemistry Pub Date : 2021-01-01 DOI:10.1515/revac-2021-0124
Sofia Soares, M. Barroso, E. Gallardo
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引用次数: 8

摘要

抗抑郁药是一类广泛应用于临床治疗多种疾病的化合物。在过去几年中,它们的消费有了相当大的增长,在一些国家已成为一个重要的公共卫生问题。由于它们是具有狭窄治疗窗口的物质,并且由于它们能够与其他类别的化合物相互作用,因此监测这些化合物具有相关性,可以最大限度地减少医疗相互作用以及副作用和毒性的风险。此外,了解它们的使用程度、通过常规毒理学测试检测它们以及开发新的检测和监测方法,对公共卫生、患者福祉以及对临床和法医情况的影响至关重要。这项工作的主要目的是对用于抗抑郁药检测和定量的生物样品进行批判性审查,特别关注样品制备技术。
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A review of current bioanalytical approaches in sample pretreatment techniques for the determination of antidepressants in biological specimens
Abstract Antidepressants are a class of compounds widely used in clinical settings for the treatment of several diseases. In the last years there has been a considerable increase in their consumption, representing an important public health issue in several countries. Because they are substances with narrow therapeutic windows, and since they are capable of interacting with other classes of compounds, monitoring of these compounds is of relevance, minimizing the risk of medical interactions as well as side and toxic effects. In addition, understanding the extent of their use, their detection through routine toxicology tests and development of new methods for detection and monitoring is of extreme importance concerning public health, patient well-being, and implications in clinical and forensic situations. The main objective of this work is to perform a critical review on the biological samples used in the detection and quantification of antidepressants with special focus on the techniques for sample preparation.
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来源期刊
Reviews in Analytical Chemistry
Reviews in Analytical Chemistry 化学-分析化学
CiteScore
7.50
自引率
0.00%
发文量
15
审稿时长
>12 weeks
期刊介绍: Reviews in Analytical Chemistry publishes authoritative reviews by leading experts in the dynamic field of chemical analysis. The subjects can encompass all branches of modern analytical chemistry such as spectroscopy, chromatography, mass spectrometry, electrochemistry and trace analysis and their applications to areas such as environmental control, pharmaceutical industry, automation and other relevant areas. Review articles bring the expert up to date in a concise manner and provide researchers an overview of new techniques and methods.
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