IgA肾病的生物标志物;最近数据的更新

Rokhsare Zareie, Mahsa Asadollahi Hamedani, Reyhaneh Sadeghian, Y. Khanchemehr, M. Belali Kharaji, E. Zaremoghadam, Negar Shahkarami, Atena Samareh Fekri
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引用次数: 0

摘要

生物标志物是可以在体内测量的分子,可以反映疾病的活动或进展。它们可用于诊断和监测疾病,预测治疗反应,并确定潜在的治疗靶点。在IgA肾病的背景下,已经研究了几种类型的生物标志物,包括蛋白质、基因表达、表观遗传和microRNA生物标志物。生物标志物有可能提高IgA肾病诊断的准确性和特异性,并预测疾病进展和对治疗的反应。然而,需要进一步的研究来验证其在更大患者群体中的诊断价值,并将其纳入临床实践。结合不同类型生物标志物的多组学方法的发展可能为更全面地了解疾病的发病机制和潜在的治疗方法提供帮助。
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Biomarkers in IgA nephropathy; an update to recent data
Biomarkers are molecules that can be measured in the body and can reflect disease activity or progression. They can be used to diagnose and monitor disease, predict treatment response, and identify potential therapeutic targets. Several types of biomarkers have been studied in the context of IgA nephropathy, including protein, gene expression, epigenetic, and microRNA biomarkers. Biomarkers have the potential to improve the accuracy and specificity of the diagnosis of IgA nephropathy and predict the disease progression and response to treatment. However, further studies are needed to validate their diagnostic value in larger cohorts of patients and to integrate them into clinical practice. The development of multi-omics approaches that combine different types of biomarkers may provide a more comprehensive understanding of the disease pathogenesis and potential treatments.
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