癌症发展中的多因子窘迫、Warburg效应、呼吸和pH失衡

IF 2.6 3区 工程技术 Q2 MECHANICS Journal of Thermal Stresses Pub Date : 2023-06-18 DOI:10.3390/stresses3020036
G. Drochioiu
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引用次数: 0

摘要

癌基因被认为在生长因子的异常调节中起重要作用,这被认为是致癌的起始事件。然而,最近的遗传和药理学研究表明,肿瘤生长需要Warburg效应(WE)。它指的是在过去十年中被广泛研究的有氧糖酵解,尽管它对癌症的影响尚不清楚。同时,大量证据表明氧化应激(OS)与多种癌症的发生和发展有关。心理社会因素(PSF),如慢性抑郁、悲伤、紧张的生活经历、易受压力的性格、情绪困扰或生活质量差,都会影响免疫系统,并导致癌症的结果。本文从生理生化机制的角度探讨了we、OS、PSF、金属离子等致癌物与不同癌症发生的关系。
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Multifactorial Distress, the Warburg Effect, and Respiratory and pH Imbalance in Cancer Development
Oncogenes are thought to play an important role in aberrant regulation of growth factors, which is believed to be an initiation event of carcinogenesis. However, recent genetic and pharmacological studies have shown that the Warburg effect (WE) is needed for tumour growth. It refers to extensively studied aerobic glycolysis over the past decade, although its impact on cancer remains unclear. Meanwhile, a large body of evidence has indicated that oxidative stress (OS) is connected with the occurrence and progression of various forms of cancer. Psychosocial factors (PSF), such as chronic depression, sadness, stressful life experiences, stress-prone personality, and emotional distress or poor quality of life affect the immune system and contribute to cancer outcomes. Here, we examine the relationship between WE, OS, PSF, metal ions, other carcinogens, and the development of different cancers from the viewpoint of physiological and biochemical mechanisms.
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来源期刊
Journal of Thermal Stresses
Journal of Thermal Stresses 工程技术-力学
CiteScore
5.20
自引率
7.10%
发文量
58
审稿时长
3 months
期刊介绍: The first international journal devoted exclusively to the subject, Journal of Thermal Stresses publishes refereed articles on the theoretical and industrial applications of thermal stresses. Intended as a forum for those engaged in analytic as well as experimental research, this monthly journal includes papers on mathematical and practical applications. Emphasis is placed on new developments in thermoelasticity, thermoplasticity, and theory and applications of thermal stresses. Papers on experimental methods and on numerical methods, including finite element methods, are also published.
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