Multi-target Therapy for Subcellular Incompatibility in Brain Disorders

Most brain disorders are caused by a number of pathogenic factors, which lead to the pathological impairment in subcellular organelles and compartments. Recent studies indicate that pathological changes in certain brain disorders include the incoordination among different nerve cells and the incompatibility among subcellular compartments. In this regard, therapeutic strategies for these brain disorders are better to act on multiple molecular and cellular targets in order to correct the neuron-specific incoordination and the subcellular incompatibility. The strategy of multi-target therapy is expected to be advanced to that of single-target therapy that leads to long-term drug-resistance or drugdependence. In this mini-review, we summarize the data about subcellular incompatibility in certain brain disorders (such as epilepsy, anxiety and depression) and propose the therapeutic principle of multiple targets for their treatments.