4-壬基酚对加里平幼鱼剂量依赖性损伤的生物化学标志物研究

Z. Eid, I. Mekkawy, U. Mahmoud
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摘要

利用生物标志物和恢复时间研究了4-壬基酚暴露对加里平Clarias gariepinus幼鱼的剂量依赖性损伤。健康幼鱼雌雄同体分为4组(7尾/组;两个复制)。第1组为对照组,其余3组分别以0.1 mg/L、0.2 mg/L和0.3 mg/L的4-壬基酚浓度暴露15 d,暴露后15 d作为恢复期。随着4-NP剂量的增加(AST、ALT、TP、Glu、Cr和UA),有显著性意义的参数(Alb和Glo)或随着剂量的增加而降低,从对照组的0.0 mg/L增加到0.3 mg/L。综上所述,肝肾功能参数反映了4-NP的肝毒性和肾毒性,在15天的恢复期后,其改变程度呈相反的下降趋势。
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BIOCHEMICAL BIOMARKERS FOR DOSE-DEPENDENT DAMAGE CAUSED BY 4-NONYLPHENOL IN THE JUVENILE CLARIAS GARIEPINUS
The present study investigates the dose-dependent damage caused by 4-nonylphenol exposure in juvenile of Clarias gariepinus using some biomarkers and the effect of recovery time. Healthy juvenile C. gariepinus of both sexes were classified into four groups (7fish/ group; two replicates). The first one was a control group, and the other three groups were exposed for 15 days to 4-nonylphenol concentrations as 0.1 mg/L, 0.2 mg/L, and 0.3 mg/L respectively, then 15 days as a recovery period after exposure time. The parameters exhibiting significance either increased with the increase of the 4-NP doses from 0.0 in the control to 0.3 mg/L (AST, ALT, TP, Glu, Cr, and UA) or decreased with such increased doses (Alb, and Glo). In conclusion, the liver and kidney functions parameters were indicated the hepatotoxicity and nephrotoxicity of 4-NP and their alterations have decreased to a great extent after a recovery period of 15-days in a reverse order.
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