心力衰竭的遗传预测评分:可能性和期望

Alex, er E. Berezin
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引用次数: 4

摘要

心力衰竭(HF)仍然是世界范围内的一个主要健康问题。目前使用的基于临床表现、超声心动图特征、生物标志物的HF风险预测评分不能提出一种个体化的风险分层方法,而在不同HF表型的患者中,不同评分的预测价值存在差异。社论评论致力于遗传风险预测评分在心衰发展易感性中的作用,以及在心衰医疗反应中的测定。还讨论了反映心衰发展中遗传和表观遗传特征变异的全新风险评分
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Genetic Predictive Scores in Heart Failure: Possibilities and Expectations
Heart failure (HF) remains a major health problem worldwide. Currently used HF risk prediction scores based on clinical findings, echocardiography features, biomarkers cannot propose an individualized approach to risk stratification, whereas there is variability in predictive value of different scores amongst patients with various HF phenotypes. The editorial commentary is devoted the role of the genetic risk prediction scores in the predisposition of HF development and assay in the HF medical care response. The brand new risk scores reflecting variabilities in genetic and epigenetic features in HF development are discussed also
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