{"title":"瑞格列奈壳聚糖纳米颗粒治疗II型糖尿病的制备及表征","authors":"N. Gautam, A. Mishra","doi":"10.24092/CRPS.2018.080402","DOIUrl":null,"url":null,"abstract":"The aim of this study was to prepare and characterize the nanoparticle formulation of Repaglinide to facilitate the development of a novel drug delivery system with improved efficacy and bioavailability. These particles were prepared by Ionotropic gelation method. Prepared formulations were evaluated for Zeta potential, Particle size Polydispersibility index, entrapment efficiency, production yield and in vitro drug release. The formulation batch F4 was found to be best formulation among all the prepared formulations because it showed least particle size, better poly dispersibility index, entrapment efficiency and in vitro drug release.","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"238 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Formulation and Characterization of Repaglinide Chitosan Nanoparticles for the Treatment of Diabetes Mellitus Type II\",\"authors\":\"N. Gautam, A. Mishra\",\"doi\":\"10.24092/CRPS.2018.080402\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The aim of this study was to prepare and characterize the nanoparticle formulation of Repaglinide to facilitate the development of a novel drug delivery system with improved efficacy and bioavailability. These particles were prepared by Ionotropic gelation method. Prepared formulations were evaluated for Zeta potential, Particle size Polydispersibility index, entrapment efficiency, production yield and in vitro drug release. The formulation batch F4 was found to be best formulation among all the prepared formulations because it showed least particle size, better poly dispersibility index, entrapment efficiency and in vitro drug release.\",\"PeriodicalId\":11053,\"journal\":{\"name\":\"Current Research in Pharmaceutical Sciences\",\"volume\":\"238 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-01-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Research in Pharmaceutical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.24092/CRPS.2018.080402\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Research in Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.24092/CRPS.2018.080402","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Formulation and Characterization of Repaglinide Chitosan Nanoparticles for the Treatment of Diabetes Mellitus Type II
The aim of this study was to prepare and characterize the nanoparticle formulation of Repaglinide to facilitate the development of a novel drug delivery system with improved efficacy and bioavailability. These particles were prepared by Ionotropic gelation method. Prepared formulations were evaluated for Zeta potential, Particle size Polydispersibility index, entrapment efficiency, production yield and in vitro drug release. The formulation batch F4 was found to be best formulation among all the prepared formulations because it showed least particle size, better poly dispersibility index, entrapment efficiency and in vitro drug release.
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