{"title":"水溶性差药物的溶解度增强研究进展","authors":"M. H. Markad, S. Mankar","doi":"10.52711/2231-5659.2022.00041","DOIUrl":null,"url":null,"abstract":"About 40% of newly discovered chemicals are lipophilic, and because of their poor solubility in water they are unable to reach the market due to their solubility in water. Solubility is one of the limitations of the oral medication regimen to obtain its required concentration in the circulatory system in order to respond scientifically. There are various techniques used to improve melting point such as, Solid dispersion, micronization, Salt formation, Inclusion complexation are some mostly use techniques Novel approaches such as nano-suspension, supercritical processing, and cryogenic technologies may improve the delivery of poorly soluble medications. One of the most challenging parts of formulation creation is drug solubility behavior.","PeriodicalId":8531,"journal":{"name":"Asian Journal of Research in Pharmaceutical Sciences","volume":"48 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Review on: Solubility Enhancement of Poorly Water Soluble Drugs\",\"authors\":\"M. H. Markad, S. Mankar\",\"doi\":\"10.52711/2231-5659.2022.00041\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"About 40% of newly discovered chemicals are lipophilic, and because of their poor solubility in water they are unable to reach the market due to their solubility in water. Solubility is one of the limitations of the oral medication regimen to obtain its required concentration in the circulatory system in order to respond scientifically. There are various techniques used to improve melting point such as, Solid dispersion, micronization, Salt formation, Inclusion complexation are some mostly use techniques Novel approaches such as nano-suspension, supercritical processing, and cryogenic technologies may improve the delivery of poorly soluble medications. One of the most challenging parts of formulation creation is drug solubility behavior.\",\"PeriodicalId\":8531,\"journal\":{\"name\":\"Asian Journal of Research in Pharmaceutical Sciences\",\"volume\":\"48 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-08-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Asian Journal of Research in Pharmaceutical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.52711/2231-5659.2022.00041\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Research in Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.52711/2231-5659.2022.00041","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Review on: Solubility Enhancement of Poorly Water Soluble Drugs
About 40% of newly discovered chemicals are lipophilic, and because of their poor solubility in water they are unable to reach the market due to their solubility in water. Solubility is one of the limitations of the oral medication regimen to obtain its required concentration in the circulatory system in order to respond scientifically. There are various techniques used to improve melting point such as, Solid dispersion, micronization, Salt formation, Inclusion complexation are some mostly use techniques Novel approaches such as nano-suspension, supercritical processing, and cryogenic technologies may improve the delivery of poorly soluble medications. One of the most challenging parts of formulation creation is drug solubility behavior.
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