镓(III)配合物与Cloxyquin配体诱导癌细胞铁下垂，是一种有效的药物，可用于分化和致瘤性癌症干细胞横纹肌肉瘤细胞

IF 4.7 3区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Bioinorganic Chemistry and Applications Pub Date : 2022-04-23 DOI:10.1155/2022/3095749

Monika Hreusova, V. Novohradský, Lenka Marková, H. Kostrhunová, I. Potočňák, V. Brabec, J. Kašpárková

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引用次数: 8

摘要

在这项工作中，镓(III)配合物与氯喹(5-氯-8-喹啉，HClQ)配体被证明可以有效抑制横纹肌肉瘤细胞的增殖，横纹肌肉瘤是一种常见的、侵袭性的、难以治疗的儿童癌症。与非癌变的人类成纤维细胞相比，它对癌细胞具有惊人的选择性。数据显示，该复合物在横纹肌肉瘤细胞中诱导铁下垂，可能是由于干扰铁代谢。重要的是，它可以杀死大块和干横纹肌肉瘤细胞。据我们所知，这是第一个基于铁以外的金属的化合物，能够在癌细胞中诱导铁凋亡。

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Gallium(III) Complex with Cloxyquin Ligands Induces Ferroptosis in Cancer Cells and Is a Potent Agent against Both Differentiated and Tumorigenic Cancer Stem Rhabdomyosarcoma Cells

In this work, gallium(III) complex with cloxyquin (5-chloro-8-quinolinol, HClQ) ligands is shown to effectively inhibit proliferation of rhabdomyosarcoma cells, the frequent, aggressive, and poorly treatable cancer of children. It offers striking selectivity to cancer cells compared to noncancerous human fibroblasts. The data reveal that the complex induces ferroptosis in rhabdomyosarcoma cells, likely due to interfering with iron metabolism. Importantly, it can kill both bulk and stem rhabdomyosarcoma cells. To the best of our knowledge, this is the first compound based on metal other than Fe capable of inducing ferroptosis in cancer cells.

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来源期刊

Bioinorganic Chemistry and Applications 化学-生化与分子生物学

CiteScore

7.00

自引率

5.30%

发文量

105

审稿时长

>12 weeks

期刊介绍： Bioinorganic Chemistry and Applications is primarily devoted to original research papers, but also publishes review articles, editorials, and letter to the editor in the general field of bioinorganic chemistry and its applications. Its scope includes all aspects of bioinorganic chemistry, including bioorganometallic chemistry and applied bioinorganic chemistry. The journal welcomes papers relating to metalloenzymes and model compounds, metal-based drugs, biomaterials, biocatalysis and bioelectronics, metals in biology and medicine, metals toxicology and metals in the environment, metal interactions with biomolecules and spectroscopic applications.