Toxinology

J. Duffus, Monica Nordberg, Douglas M. Templeton
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引用次数: 2

摘要

近年来,毒理学研究领域有了长足的发展。一方面,它详细研究有毒的动物、植物和微生物,了解它们对目标的作用方式。另一方面,它探索毒素和毒液的生化组成、基因组学和蛋白质组学,以了解它们与生命形式(特别是人类)的三种相互作用、解毒剂的开发和探索它们的药理潜力。因此,毒理学与生物化学、分子生物学、解剖学和药理学有着密切的联系。此外,还有一个快速发展的应用分支,即临床毒理学,它涉及了解和管理毒素对人体的医学作用。鉴于毒素导致的死亡在全球范围内的巨大影响,以及毒液在目前无法治愈的疾病(例如糖尿病、慢性疼痛)的药物生产中的潜力,该领域的持续研究和发展迫在眉睫。这导致了该领域研究的增长,以及随之而来的通过期刊和书籍出版的学术产出。尽管生物医学科学领域的文献越来越多,但仍然没有收集所有重要的生物化学、生物医学和与毒理学有关的临床见解的包罗万象的参考工作。由12卷组成,毒理学提供了全面和权威的毒理学主要领域的覆盖,从基本概念到新的发展和应用领域。每一卷包括一个集中和精心挑选的贡献,从领先的名字在主题的集合。系列标题生物毒素与生物恐怖主义亚太和非洲的临床毒理学蜘蛛毒液蝎子毒液海洋和淡水毒素毒液基因组学和蛋白质组学蛇毒有毒动物及其毒液的进化微生物毒素植物毒素毒素和药物发现澳大利亚、美国和欧洲的临床毒理学
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Toxinology
In recent years, the field of toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast-developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, diabetes, chronic pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever-growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to toxinology. Composed of 12 volumes, Toxinology provides comprehensive and authoritative coverage of the main areas in toxinology, from fundamental concepts to new developments and applications in the field. Each volume comprises a focused and carefully chosen collection of contributions from leading names in the subject. Series Titles 1. Biological Toxins and Bioterrorism 2. Clinical Toxinology in Asia Pacific and Africa 3. Spider Venoms 4. Scorpion Venoms 5. Marine and Freshwater Toxins 6. Venom Genomics and Proteomics 7. Snake Venoms 8. Evolution of Venomous Animals and Their Venoms 9. Microbial Toxins 10. Plant Toxins 11. Toxins and Drug Discovery 12. Clinical Toxinology in Australia, America, and Europe
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Toxinology The Intracellular Journey of Shiga Toxins Glucosylation of Rho/Ras Proteins by Lethal Toxin – Implications of Actin Re-Organization and Apoptosis in C. Sordellii-Associated Disease Clostridium Botulinum C3 Exoenzyme: Rho-Inactivating Tool in Cell Biology and a Neurotrophic Agent Clostridium Perfringens Toxins Involved in Mammalian Veterinary Diseases
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