聚合物及聚合物复合材料表面微真菌菌落发育的定量评价

E. A. Isaev, F. Doronin, A. G. Evdokimov, D. Pervukhin, Y. Rudyak, G. Rytikov, V. Kornilov, V. G. Nazarov
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引用次数: 0

摘要

为了确保电子和移动保健技术能够广泛使用,不仅需要形成适当的信息技术基础设施,还需要开发处理大量个人信息的有效算法。用于记录生理过程的医疗设备的开发还涉及创造创新的生物兼容材料,使传感器和医疗传感器能够在24/7模式下连续工作。考虑到在医疗设备中使用大容量热塑性塑料和弹性体的长期积极经验,似乎有希望使用相应的聚合物作为医疗用途的可穿戴电子产品的主要材料。同时,为了确保所讨论材料的生物相容性,有必要尽量减少病原微生物在与活组织接触的表面上发展的可能性。这类致病性生物(许多危险疾病的病原体——真菌病)包括某些类型的微真菌——微菌类(特别是黑曲霉;土曲霉;西林青霉菌。本文考察了气相氟化表面改性对几种热塑性塑料(聚氯乙烯、聚丙烯、低密度聚乙烯、聚对苯二甲酸乙二醇酯)和弹性体(丁基橡胶和丁二烯-丁腈橡胶,以及乙烯、丙烯和二环戊二烯共聚物)制成的实验样品表面上混合菌落的性质和发展程度的影响。使用早先开发的原始方法定量描述菌落的性质和发展程度。利用扫描电子显微镜(SEM)和红外傅立叶光谱(IRFS)研究了氟化对实验样品表面和近表层纳米结构和化学成分的影响。采用线性化双曲模型描述了氟化反应的动力学和效率,模型参数采用最小二乘法设定。
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Quantitative Assessment of the Development of Micromycete Colony on the Surfaces of Polymers and Polymer Composites
The need to ensure the possibility of widespread use of electronic and mobile health-saving technologies requires not only the formation of an appropriate information technology infrastructure and the development of effective algorithms for processing a large amount of personal information. Development of medical devices for recording physiological processes also involves the creation of innovative biologically compatible materials that allow sensors and medical sensors to work continuously in 24/7 mode. Taking into account the long-term positive experience of using large-capacity thermoplastics and elastomers in medical equipment, it seems promising to use the corresponding polymers as the main materials of wearable electronics for medical purposes. At the same time, to ensure the biological compatibility of the materials under discussion, it is necessary to minimize the possibility of the development of pathogenic microorganisms on surfaces in contact with living tissues. This type of pathogenic organisms (pathogens of a number of dangerous diseases – mycoses) includes some types of microscopic fungi - micromycetes (in particular, Aspergillus niger van Tiegem; Aspergillus terreus Thom; Penicillium cycopium Westling). The article examines the effect of surface modification by gas-phase fluorination on the nature and degree of development of a mixed colony of micromycetes on the surfaces of experimental samples made of several types of thermoplastics (polyvinyl chloride, polypropylene, low-density polyethylene, polyethylene terephthalate) and elastomers (butyl- and butadiene-nitrile rubbers, as well as ethylene, propylene and dicyclopentadiene copolymers). The nature and degree of development of colonies are quantitatively described using the original methodology developed earlier. The effect of fluorination on the nanotexture and chemical composition of the surface and near-surface layers of experimental samples was demonstrated using scanning electron microscopy (SEM) and IR Fourier spectroscopy (IRFS). The dynamics and efficiency of fluorination are described using a linearized hyperbolic model, the parameters of which are set by the least squares method.
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来源期刊
Mathematical Biology and Bioinformatics
Mathematical Biology and Bioinformatics Mathematics-Applied Mathematics
CiteScore
1.10
自引率
0.00%
发文量
13
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