The formulations in Rasayogsagar for treating toxicity: Critical review

Background: In the current era, different toxicants are a major problem for human Owing to industrialization and civilization, people are embedded in the test-tube of toxins. Different kinds of toxicants, which are called xenobiotics, found in the form of chemicals, pesticides, coloring agents, and antibiotics, which enter into the body through different routes such as oral, dermal, and inhalation, play an important role as a etiological factor for the pathology of different diseases such as hypertension, diabetes mellitus, cancer, and so on. All these artificial poisons are considered to be Kritrim Visha, which are also called Gara Visha in Ayurveda, which is described to be one of the causative factors to cause disease conditions. So, it is necessary to identify those preparations or formulations which act as an anti-toxic action. The classical text, i.e., Rasayogsagar, has mentioned thousands of preparations, among them about 74 are Vishaghna Yoga (anti-toxic preparations) which have been specifically indicated either in animate or in inanimate toxicity or in both. These formulations in the modern era have a great importance to reduce the toxicity level in human beings. So, these preparations must be prepared and made available everywhere following the guidelines of preparation mentioned in Rasayogsagar, which could play to pacify the toxic substance and prevent the harmful effects in human beings. Aims and Objectives: The aim of this study is as follows: (i) To study the indication of different preparations mentioned in Rasayogsagar for different toxic manifestations. (ii) A detailed literary study of contents and methods of preparations of Vishaghna (anti-toxic) with doses and route of administration. Materials and Methods: The article is based on literary review regarding anti-toxic action (Vishaghna) of various kinds of preparations, which has been collected and compiled from Ayurvedic compendium (i.e., Rasayogsagar). Results and Conclusion: In total, 74 anti-toxic (Vishaghna) formulations have been found in Rasayogsagar. Most of them have found to be specifically indicated in anti-toxic action-specific (Visha Rogadhikar) and some of them have been indicated in other disease conditions but have anti-toxic properties (Vishaghna) also.