毒蛇科蛇毒的药理研究

Chellapandi Paulchamy
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引用次数: 6

摘要

蛇毒是许多不同蛋白质和酶的组合。这些蛋白质中有许多对人类无害,但有些是毒素。蛇毒的作用包括促凝血和抗凝血、神经毒性、真菌毒性、肾毒性、心脏毒性和坏死毒性。本文只着重介绍毒蛇毒液的主要成分及其对细胞的药理作用。讨论了磷脂酶a2、l -氨基酸氧化酶和金属蛋白酶等酶的优势,而非酶蛋白如华普林家族蛋白、血小板聚集因子和c型凝集素样蛋白的优势。最近,一些公共领域的蛇毒数据库发布,其中包含自然史注释,毒蛇图片,分布图以及每条蛇及其毒液的信息。因此,我们得出结论,本文所提供的信息将对研究人员从蛇毒中研究新的人类治疗方法更有帮助。
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Pharmacological perspectives of snake venoms from Viperidae family
Snake venom is a combination of many different proteins and enzymes. Many of these proteins are harmless to humans, but some are toxins. Snake venoms effects include pro- and anti-blood coagulation, neurotoxicity, mycotoxicity, nephrotoxicity, cardiotoxicity and necrotoxicity. This article has focused only on the principle components of viperidae venoms and their corresponding pharmacological actions on cells. Is was also discussed the advantages of enzymes like phospholipase A 2 , L-amino acid oxidase, and metalloprotease while non-enzymatic proteins include warprin family proteins, platelet aggregation factors and C-type lectin-like protein. Most recently, few public-domain snake venoms database are released which contains natural history notes, pictures of venomous snakes, distribution maps and information about each individual snake and its venom. Thus, we conclude that the given information in this review will be more useful for researchers to investigate novel human therapeutics from snake venoms.
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