MOLECULAR COMPLEXES OF MONOAMMONIUM SALT OF GLYCYRRHIZIC ACID WITH SOME UREA AND THEIR ANTIBIOTIC ACTIVITY

This article reports on obtaining the inclusion compounds of the monoammonium-glycyrrhizin salts with urea, thiourea and methylolthiourea. The compounds were obtained by the liquid phase way, and their structures were characterized by the UV- and IR-Spectroscopic methods. Proceeding from the spectral data, it was concluded that the complexation occurs through the interaction of polar groups of the components. The composition of the complexes was studied using the method of isomolar series. Equilibrium constants and changes in Gibbs free energy of the complexation process were also calculated. The biological activity of complex compounds was studied on the example of fungicidal activity of one of the most common pathogenic fungus Fusarium. The obtained compounds can be used as as fungicides and stimulants in agriculture.