新型光学生物传感器技术发展中的固定化细胞生物反应器产业化

A. Koutinas, Theano Petsi, Sissy Panitsa, M. Kanellaki
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引用次数: 0

摘要

本文介绍了一种基于荧光假单胞菌HK44细胞固定化的新型光学生物传感器的发展,该传感器采用纳米和微管纤维素(TC)以及碳水化合物纳米管(CHNTs)和碳水化合物微管(CHMTs)的混合物。方法如下,这种生物催化剂可以工业化使用一个单一的坦克固定化细胞生物反应器(ICB)。通过设计具有质量和能量平衡的工艺流程图,在此框架内进行了技术经济分析。根据其案例分析,投资为22.78万欧元,日生产成本为1434欧元,日最高附加值为2.5万欧元。讨论表明,生物传感器领域正在形成新的研究建议和新的研究理念。研究结果得到了有关ICB地区发展的论文的支持。导致这一评论的问题是ICB的工业化,在使用固定细胞的简单生物传感器开发的情况下,这是目标。
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Immobilized Cell Bioreactor Industrialization in the Development of an Innovative Optical Biosensor Technology
This commentary shows the development of a new optical biosensor, based on cell immobilization of Pseudomonas Fluorescens HK44, in nano and micro-tubular cellulose (TC) and a mixture of carbohydrate nanotubes (CHNTs) and carbohydrate micro-tubes (CHMTs). Methodology follows, this biocatalyst can be industrialized with the use of a single tank immobilized cell bioreactor (ICB). A techno-economic analysis was conducted within the framework of it by designing a process flow sheet with mass and energy balance. According to its case study, the investment is 227,800 euros, and the daily production cost is 1434 euros, with a maximum daily added value of 25,000 euros. The discussion revealed that novel research proposals and a novel study concept are being developed in the field of biosensors. The results are supported by papers published on ICB area development. The problem that leads to this commentary is industrialization of ICB, in the case of a simple biosensor development using immobilized cells and it is the objective.
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