三级医院急性缺血性脑卒中患者血清铁蛋白的相关性研究

Umashankar Ranjan, Kanmani Panneerselvam
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摘要

背景:中风是全球死亡和发病的主要原因。确定预后标志物和死亡率预测因子对于成功干预和治疗缺血性卒中至关重要。本研究旨在结合美国国立卫生研究院卒中量表(NIHSS)和MRS卒中量表,检验血清铁蛋白作为卒中严重程度的预后指标的作用。此外,还研究了血清铁蛋白与中风相关危险因素的关系。方法:本研究采用横断面法。143例急性缺血性脑卒中患者在卒中发病后24小时内到普通内科门诊就诊。只选取符合纳入和排除标准的患者进行分析。急性缺血性脑卒中患者入院时需口头同意、医学背景、血常规、神经系统检查、CT扫描、NIHSS评分、治疗方案、抗水肿措施、4周后功能恢复的改良Rankin量表。结果:本研究中男性占80%,女性占20%。大多数研究参与者年龄在51-60岁之间(38%)。平均年龄58.87岁,标准差为11.41。约35%为吸烟者,38%为酗酒者,56%为糖尿病患者,68%为高血压患者,35%为脂质紊乱患者。根据NIHSS量表和修正Rankin量表,血清铁蛋白与脑卒中严重程度的相关性有统计学意义。结论:该研究表明血清铁蛋白可作为急性缺血性脑卒中患者预后的指示性指标。然而,随访期间的监测并未显示出任何益处。目前的研究美化了简单使用血清标记物。
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Association of serum ferritin in patients with acute ischemic stroke in tertiary care hospital
Background: Stroke is a major cause of mortality and morbidity globally. Identifying prognostic markers and mortality predictors is essential for successful intervention and treatment of ischemic stroke. The study aims to examine the role of serum ferritin as a prognostic indicator for stroke severity in conjunction with national institute of health stroke scale (NIHSS) and MRS stroke scales. Furthermore, the association of serum ferritin and several associated risk factors for stroke was also studied. Methods: This study conducted was cross-sectional. 143 patients with acute ischemic stroke who attended the general medicine OPD within 24 hours of admission after the onset of stroke were taken into consideration. Only those patients who matched the inclusion and exclusion criteria were taken for analysis. Acute ischemic stroke patients were admitted with verbal consent, medical background, routine blood, neurological examination, and CT scan, NIHSS scoring, treatment protocols, anti-edema measures, and modified Rankin scale for functional recovery after four weeks. Results: In the present study, 80% were males, and 20% were females. Most study participants were 51-60 years (38%). The mean age is 58.87 years, and the standard deviation is 11.41. About 35% were smokers, 38% were alcoholics, 56% were diabetic, 68% were hypertensives, and 35% had lipid disorders. There is a statistically significant correlation between serum ferritin and the severity of stroke based on the NIHSS scale and the Modified Rankin scale. Conclusions: The study demonstrates the use of serum ferritin as an indicative marker for prognosis patients having an acute ischemic stroke. However, monitoring during follow-up did not show any benefit. The current study glorifies the simplistic use of a serum marker.
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