ras相关C3肉毒毒素底物1在神经系统疾病病理生理中的作用

IF 1.3 Q4 CLINICAL NEUROLOGY Brain Hemorrhages Pub Date : 2022-12-01 DOI:10.1016/j.hest.2022.05.005
Ngoc Mai Le, Jun Li
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引用次数: 0

摘要

ras相关C3肉毒毒素底物(Rac1)是一种小的GTPase,它通过传递膜结合受体的信息来监测外部信号并激活下游级联反应,发挥其生理和病理作用。它是调节肌动蛋白细胞骨架聚合、组织、功能和动力学所必需的。Rac1是一种被广泛研究的分子,其在各种脑部疾病和疾病中的作用已在啮齿动物和体外模型中得到研究。本文就Rac1在神经系统疾病病理生理中的作用、在不同神经系统疾病中的分子通路以及在不同细胞类型和神经系统疾病阶段的有益和有害病理生理作用进行综述。
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Ras-related C3 botulinum toxin substrate 1 role in pathophysiology of neurological diseases

Ras-related C3 botulinum toxin substrate (Rac1) is a small GTPase that monitors external signals and activates downstream cascades by transmitting information from membrane-bound receptors to exert its physiological and pathological effects. It is essential for regulating actin cytoskeleton polymerization, organization, function, and dynamics. Rac1 is a widely studied molecule, and its role in various brain disorders and diseases has been studied in rodent and vitro models. This review discusses the involvement of Rac1 in the pathophysiology of neurological diseases, its molecular pathway in different neurological diseases, and its beneficial and detrimental pathophysiological role in different cell-type and neurological disease phases.

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来源期刊
Brain Hemorrhages
Brain Hemorrhages Medicine-Surgery
CiteScore
2.90
自引率
0.00%
发文量
52
审稿时长
22 days
期刊最新文献
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