辛烯基丁二酸酐淀粉及其多电解质配合物在皮克林乳液中的稳定作用

Q4 Pharmacology, Toxicology and Pharmaceutics Pharmaceutical Sciences Asia Pub Date : 2022-01-01 DOI:10.29090/psa.2022.05.22.198

Nattawut Charoenthai, Kun Sodalee, S. Puttipipatkhachorn

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引用次数: 0

摘要

皮克林乳剂又称固体颗粒稳定乳剂，因其稳定性高、无毒等优点，在医药产品中得到越来越多的应用。由于在传统乳化剂中用作乳化剂的低分子量表面活性剂具有不良的毒性，生物聚合物的固体颗粒已被用作皮克林乳剂的稳定剂。综述了近年来利用辛烯基丁二酸酐淀粉及其多电解质配合物作为皮克林乳液稳定剂的研究进展。OSA淀粉基皮克林乳剂已被报道制备了多种剂型，如乳剂、纳米乳剂、微胶囊、纳米胶囊和可再分散干乳剂。所获得的信息表明，皮克林乳剂在制药工业中的应用和实际用途呈增长趋势。

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Octenyl succinic anhydride starch and its polyelectrolyte complexes as stabilizers in Pickering emulsions

Pickering emulsions, also known as emulsions stabilized by solid particles, have been increasingly applied in pharmaceutical products due to their high stability and non-toxicity. Due to unwanted toxicity from low molecular weight surfactants used as emulsifiers in classical emulsions, solid particles of biopolymers have been used as stabilizers in Pickering emulsions. This review summarizes the recent research on using octenyl succinic anhydride (OSA) starch and its polyelectrolyte complexes as stabilizers in Pickering emulsions. OSA starch-based Pickering emulsion has been reported to prepare various dosage forms such as emulsion, nanoemulsion, microcapsules, nanocapsules, and redispersible dry emulsion. The information obtained indicates the increasing trend in the application and practical uses of Pickering emulsions in the pharmaceutical industry.

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来源期刊

Pharmaceutical Sciences Asia Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： The Pharmaceutical Sciences Asia (PSA) journal is a double-blinded peer-reviewed journal in English published quarterly, by the Faculty of Pharmacy, Mahidol University, Thailand. The PSA journal is formerly known as Mahidol University Journal of Pharmaceutical Sciences and committed to the timely publication of innovative articles and reviews. This journal is available in both printed and electronic formats. The PSA journal aims at establishing a publishing house that is open to all. It aims to disseminate knowledge; provide a learned reference in the field; and establish channels of communication between academic and research expert, policy makers and executives in industry and investment institutions. The journal publishes research articles, review articles, and scientific commentaries on all aspects of the pharmaceutical sciences and multidisciplinary field in health professions and medicine. More specifically, the journal publishes research on all areas of pharmaceutical sciences and related disciplines: Clinical Pharmacy Drug Synthesis and Discovery Targeted-Drug Delivery Pharmaceutics Biopharmaceutical Sciences Phytopharmaceutical Sciences Pharmacology and Toxicology Pharmaceutical Chemistry Nutraceuticals and Functional Foods Natural Products Social, Economic, and Administrative Pharmacy Clinical Drug Evaluation and Drug Policy Making Antimicrobials, Resistance and Infection Control Pharmacokinetics and Pharmacodynamics.