数字微流控的twDEP和EWOD高效滴内颗粒浓度和分离

Yuejun Zhao, U. Yi, S. Cho
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引用次数: 12

摘要

本文描述了高效的液滴颗粒浓缩/分离(效率超过92%),其中目标颗粒通过行波介质电泳(twDEP)在液滴内浓缩/分离,随后的EWOD(介电电润湿)驱动将富含目标的区域物理地分割成单个液滴。这种液滴内方法将为数字(基于液滴的)微流体提供一种新的分离/浓缩功能[1],从而可能消除采用传统的基于连续流的分离方法的必要性。
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Highly efficient in-droplet particle concentration and separation by twDEP and EWOD for digital microfluidics
This paper describes highly efficient in-droplet particle concentrations/separations (over 92% efficiency), where target particles are concentrated/separated within a droplet by traveling wave dielectrophoresis (twDEP) and a subsequent EWOD (electrowetting-on-dielectric) actuation physically splits target-rich regions into individual droplets. This in-droplet method will provide a new functionality of separation/concentration for digital (droplet-based) microfluidics [1], thereby possibly eliminating the necessity of adopting the conventional continuous-flow-based separation methods.
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