纳米颗粒局部给药研究进展

A. A. Shaikh, J. Pawar, Sachin J. Anbhule, V. Kakade
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引用次数: 0

摘要

本文将对纳米颗粒在局部给药中的应用进行综述。在过去的25年里,已经进行了几项实验,以消除皮肤输送的一些障碍。这些研究导致了技术上相当有限的进步。最近的一种方法是增加药物在载体中的浓度,以增加药物进入和通过皮肤的流量。疏水和亲水药物都可以使用纳米颗粒输送,纳米颗粒具有在规定条件下长时间释放药物的能力。它还增加了患者的依从性。脂质体和固体脂质纳米颗粒具有作为局部药物递送方法的潜力。
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Review on nanoparticles for topical drug delivery
An overview of the use of nanoparticles for topical drug delivery will be given in this review paper. Several experiments have been conducted in the past 25 years to remove some of the obstacles to skin delivery. These investigations have led to a rather modest progress in technology. A more recent method involved increasing the medication's concentration in the carrier to increase drug flow into and through the skin. Hydrophobic and hydrophilic medications can be delivered using nanoparticles, which have the ability to release drugs under regulated conditions over an extended period of time. It also increases patient compliance. Liposomes and solid lipid nanoparticles have the potential to be useful as topical medication delivery methods.
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