一锅三组分法合成几种新型吡唑啉类化合物及其相应的噻唑类化合物

R. H. H. Salih, F. Hawaiz
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引用次数: 1

摘要

在目前的研究中;以4(4′-氯代酶氧基)苯乙酮、硫代氨基脲和不同取代苯甲醛为原料,在无水乙醇中进行一锅三组分回流搅拌反应,得到了一系列新的吡唑啉衍生物{3-(4-[4′-氯代酶氧基)苯基)-5-(取代苯基)- 4,5-二氢吡唑-1-碳硫酰胺},收率高,反应时间短。之后的化合物通过与4-溴苯酰溴在乙醇中反应转化为相应的噻唑衍生物。通过FT-IR、1H-NMR、13C-NMR和DEPT-135光谱对新合成化合物的结构进行了鉴定。
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Synthesis of Some New Pyrazolines via One-Pot Three Component Technique and Their Corresponding Thiazole Compounds
In the present study; a one-pot three component reaction between4(4'-chlorobenzyloxy)acetophenone , thiosemicarbazide and different substituted benzaldehydes in absolute ethanolunder reflux with stirring has been used to give a new series of pyrazoline derivatives {3-(4-[4'-chlorobenzyloxy)phenyl)-5-(substituted-phenyl]-4,5-dihydropyrazole-1-carbothioamide}in highyields and short reaction times. . The later compounds were converted to their correspondingthiazole derivatives through reacting with 4-bromophenacyl bromide in ethanol. , The structures of the newly synthesized compounds were identified on the bases of their FT-IR, 1H-NMR, 13C-NMR and DEPT-135 spectra.
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