Pradeep D. Nile, Aditya A. Kulkarni, Ashok A.Shinde, Archana N. Panche, Sanjay N. Harke
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Extraction, purification and anti-cancer activity of curcumin
Turmeric has long been used as a strong anti-inflammatory in Indian drug systems. Turmeric is rich in curcuminoids that have different chemical, physico-chemical properties. Current work reports exraction of curcuminoids, curcumin using the Soxhlet extractor. Purification and quantification of curcumin is performed by chromatography. The yield percentage of curcumin reported 4.09% by the Soxhlet extraction method. Different solvent were used for extraction, among them acetone extract was with high yield of curcumin. Individual curcumin extract analysed using UV-VIS Spectroscopy and HPLC. Our results showed that the Salem turmeric contains highest percentage of curcumin. The in vitroMTT assay on the U87MG glioma cell line demanstrated anti-cancer activity of isolated curcumin.
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