木槿天然分离黏液的定性定量气相色谱-质谱分析与表征

Sushma Chaudhary, Manjul Singh, A. Rawat
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摘要

德干大麻含有丰富的粘液,价值巨大。本研究对德干大麻的胶浆进行了检测,并对其进行了气相色谱-质谱分析,以确定胶浆中糖成分的存在,为药物配方的开发提供了依据。浆液为9.54% w/w,颜色偏白,无味,有特有气味。理化性质表明,胶浆具有足够的水分(9.34% w/w), ph值为中性,在热水中可溶,在有机溶剂中不溶,在冷水中膨胀形成凝胶。胶浆的GC-MS分析显示,葡萄糖,果糖,蔗糖,麦芽糖和木糖的存在范围具有科学意义,特别是植物聚合物为基础的赋形剂和医药产品的涂层材料。本研究表明,德干麻浆液具有很高的药用价值,可作为药物制剂的赋形剂和包衣材料。
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Qualitative and quantitative gas chromatography-mass spectroscopy analysis and characterization of naturally isolated mucilage in Hibiscus cannabinus L. (Malvaceae)
Deccan hemp is rich in mucilage and of immense value. This study was performed to examine the mucilage of Deccan hemp and its (Gas Chromatography-Mass Spectroscopy) analysis was performed to identify the presence of sugar composition in mucilage for the development of pharmaceutical formulation. Mucilage was found to be 9.54% w/w which was off white in colour, tasteless and with characteristic odour. Physicochemical characterization revealed that mucilage has enough moisture that is 9.34 % w/w and is of neutral pH. It was found to be soluble in hot water and insoluble in organic solvents while in cold water mucilage swelled to form a gel. The GC-MS analysis of mucilage showed the presence of glucose, fructose, sucrose, maltose and xylose that scope to be of scientific relevance particularly plant polymer based excipient and coating material in pharmaceutical products. The present investigation showed that Deccan hemp mucilage has high pharmaceutical significance it can be used as excipient and coating material in pharmaceutical formulation.
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