去甲睾酮与甲孕酮治疗功能失调性子宫出血的疗效比较:一项前瞻性观察研究

Mohammad Irfan Abdul Kader, V. Karthikeyan, S. J
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摘要

功能失调性子宫出血(DUB)是指在未怀孕的情况下发生的子宫体出血,其规律性、数量、频率或持续时间异常。甲孕酮(MPA)和去甲睾酮(NE)是一种雌性激素(黄体酮)。为了治疗功能失调性子宫出血,本研究试图确定MPA和NE如何起作用。材料和程序在Palakkad的一家医院进行了为期三个月的前瞻性观察研究。采用PBAC评分法分析了MPA和NE的有效性。使用Microsoft Excel 2007对病例进行录入,并进行描述性统计分析。结果与讨论本研究共有71名受访者,年龄在18 - 35岁及以上。71人中有32人获得了MPA,而39人获得了NE。DUB在35岁以上的女性中更为普遍(NE-56.4%, MPA-75%)。DUB常见于超重个体(NE: 56.4%;MPA: 50)。服用两种药物后,PBAC评分下降。根据这项研究,去甲睾酮比这两种药物都更有效。
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A Comparative Study on Efficacy of Norethisterone and Medroxyprogestrone in the Management of Dysfunctional Uterine Bleeding: A Prospective Observational Study
Dysfunctional uterine bleeding (DUB) is defined as bleeding from the uterine corpus that is abnormal in regularity, volume, frequency, or duration and occurs in the absence of pregnancy. Methylprogesterone (MPA) and Norethisterone (NE) are a sort of female hormone (progestin).To cure dysfunctional uterine bleeding, this study sought to determine how MPA and NE worked. Materials and Procedures Over three months, a prospective observational study was conducted at a hospital in Palakkad. The usefulness of MPA and NE is analyzed by using the PBAC score method. Using Microsoft Excel 2007, the cases were entered, and descriptive statistical analysis was then performed. Results and Discussion There were 71 respondents in this study, with ages ranging from 18 to 35 and older. 32 of the 71 people received MPA, whereas 39 of them acquired NE. DUB was much more prevalent in women over 35 (NE-56.4% and MPA-75%). DUB is usually seen in overweight individuals (NE: 56.4%; MPA: 50.). The PBAC score dropped after both medications were administered. Norethisterone is more effective than either of the drugs, as per this study.
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