S. Shyaula, Teresa Shah, R. Rathnayaka, S. Samarakoon, Erendra Manandhar, J. Yue, M. Manandhar
{"title":"针叶Usnea acaulifera分离化合物的细胞毒性研究","authors":"S. Shyaula, Teresa Shah, R. Rathnayaka, S. Samarakoon, Erendra Manandhar, J. Yue, M. Manandhar","doi":"10.3126/jncs.v43i2.53357","DOIUrl":null,"url":null,"abstract":"Atranorin 1, Usnic acid 2, and D-Arabinitol 3 were isolated from Usnea aciculifera by extensive column chromatography. The structures were elucidated based on the comprehensive spectral analysis including FT IR, GC MS, ESI MS, 13C NMR, and 1H NMR. The compounds were evaluated for their cytotoxic activity against LN-229 glioblastoma cancer cell line by performing Sulforhodamine B assay (SRB). Usnic acid 2 showed strong cytotoxic activity against LN-229 glioblastoma cancer cell with an IC50 value of 3.09 μg/mL.","PeriodicalId":16483,"journal":{"name":"Journal of Nepal Chemical Society","volume":"519 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cytotoxicity of Compounds Isolated from Usnea aciculifera\",\"authors\":\"S. Shyaula, Teresa Shah, R. Rathnayaka, S. Samarakoon, Erendra Manandhar, J. Yue, M. Manandhar\",\"doi\":\"10.3126/jncs.v43i2.53357\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Atranorin 1, Usnic acid 2, and D-Arabinitol 3 were isolated from Usnea aciculifera by extensive column chromatography. The structures were elucidated based on the comprehensive spectral analysis including FT IR, GC MS, ESI MS, 13C NMR, and 1H NMR. The compounds were evaluated for their cytotoxic activity against LN-229 glioblastoma cancer cell line by performing Sulforhodamine B assay (SRB). Usnic acid 2 showed strong cytotoxic activity against LN-229 glioblastoma cancer cell with an IC50 value of 3.09 μg/mL.\",\"PeriodicalId\":16483,\"journal\":{\"name\":\"Journal of Nepal Chemical Society\",\"volume\":\"519 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-04-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Nepal Chemical Society\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3126/jncs.v43i2.53357\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nepal Chemical Society","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3126/jncs.v43i2.53357","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Cytotoxicity of Compounds Isolated from Usnea aciculifera
Atranorin 1, Usnic acid 2, and D-Arabinitol 3 were isolated from Usnea aciculifera by extensive column chromatography. The structures were elucidated based on the comprehensive spectral analysis including FT IR, GC MS, ESI MS, 13C NMR, and 1H NMR. The compounds were evaluated for their cytotoxic activity against LN-229 glioblastoma cancer cell line by performing Sulforhodamine B assay (SRB). Usnic acid 2 showed strong cytotoxic activity against LN-229 glioblastoma cancer cell with an IC50 value of 3.09 μg/mL.
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