Priya Bisen, A. Chaturvedi, A. Ganeshpurkar, Nazneen Dubey
{"title":"苋菜叶乙醇提取物对异丙肾上腺碱致大鼠心肌梗死的心脏保护作用","authors":"Priya Bisen, A. Chaturvedi, A. Ganeshpurkar, Nazneen Dubey","doi":"10.5530/fra.2020.1.5","DOIUrl":null,"url":null,"abstract":"Cite this article: Bisen P, Chaturvedi A, Ganeshpurkar A, Dubey N. Cardioprotective Effect of Amaranthus cruentus Extracton Isoprenaline Induced Myocardial Infraction in Rats. Free Radicals and Antioxidants. 2020;10(1):23-8. ABSTRACT Objectives: The present study is focused to evaluate cardioprotective activity of ethanolic extract of Amaranthus cruentus. Methods: Amaranthus cruentus extract (Dose 200mg/kg and 400mg/kg) in isoprenaline induced myocardial infarction in rats. The ethanolic extract of Amaranthus cruentus was prepared and subjected to acute toxicity in albino rats. The extract was given orallyat two different doses 200mg/kg and 400mg/. Isoprenaline was administered subcutaneously (85mg/kg s.c.). Results: The histopathological examination revealed mild infarction and inflammation in isoprenaline treated rats. The ethanolic extract of Amaranthus cruentus showed significant cardio protective effect by decreasing the serum level of LDL and VLDL cholesterol levels. The biochemical parameters (AST, ALT and ALP) and HDL cholesterol levels were restored. Conclusion: The outcome of the present study suggested cardioprotective activity of Amaranthus cruentus extract.","PeriodicalId":12388,"journal":{"name":"Free Radicals and Antioxidants","volume":"130 1","pages":"24-28"},"PeriodicalIF":0.0000,"publicationDate":"2020-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cardioprotective Effect of Ethanolic Extract of Leaves of Amaranthus cruentus in Isoprenaline-Induced Myocardial Infarction in Rats\",\"authors\":\"Priya Bisen, A. Chaturvedi, A. Ganeshpurkar, Nazneen Dubey\",\"doi\":\"10.5530/fra.2020.1.5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Cite this article: Bisen P, Chaturvedi A, Ganeshpurkar A, Dubey N. Cardioprotective Effect of Amaranthus cruentus Extracton Isoprenaline Induced Myocardial Infraction in Rats. Free Radicals and Antioxidants. 2020;10(1):23-8. ABSTRACT Objectives: The present study is focused to evaluate cardioprotective activity of ethanolic extract of Amaranthus cruentus. Methods: Amaranthus cruentus extract (Dose 200mg/kg and 400mg/kg) in isoprenaline induced myocardial infarction in rats. The ethanolic extract of Amaranthus cruentus was prepared and subjected to acute toxicity in albino rats. The extract was given orallyat two different doses 200mg/kg and 400mg/. Isoprenaline was administered subcutaneously (85mg/kg s.c.). Results: The histopathological examination revealed mild infarction and inflammation in isoprenaline treated rats. The ethanolic extract of Amaranthus cruentus showed significant cardio protective effect by decreasing the serum level of LDL and VLDL cholesterol levels. The biochemical parameters (AST, ALT and ALP) and HDL cholesterol levels were restored. Conclusion: The outcome of the present study suggested cardioprotective activity of Amaranthus cruentus extract.\",\"PeriodicalId\":12388,\"journal\":{\"name\":\"Free Radicals and Antioxidants\",\"volume\":\"130 1\",\"pages\":\"24-28\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-08-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Free Radicals and Antioxidants\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5530/fra.2020.1.5\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Free Radicals and Antioxidants","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5530/fra.2020.1.5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Cardioprotective Effect of Ethanolic Extract of Leaves of Amaranthus cruentus in Isoprenaline-Induced Myocardial Infarction in Rats
Cite this article: Bisen P, Chaturvedi A, Ganeshpurkar A, Dubey N. Cardioprotective Effect of Amaranthus cruentus Extracton Isoprenaline Induced Myocardial Infraction in Rats. Free Radicals and Antioxidants. 2020;10(1):23-8. ABSTRACT Objectives: The present study is focused to evaluate cardioprotective activity of ethanolic extract of Amaranthus cruentus. Methods: Amaranthus cruentus extract (Dose 200mg/kg and 400mg/kg) in isoprenaline induced myocardial infarction in rats. The ethanolic extract of Amaranthus cruentus was prepared and subjected to acute toxicity in albino rats. The extract was given orallyat two different doses 200mg/kg and 400mg/. Isoprenaline was administered subcutaneously (85mg/kg s.c.). Results: The histopathological examination revealed mild infarction and inflammation in isoprenaline treated rats. The ethanolic extract of Amaranthus cruentus showed significant cardio protective effect by decreasing the serum level of LDL and VLDL cholesterol levels. The biochemical parameters (AST, ALT and ALP) and HDL cholesterol levels were restored. Conclusion: The outcome of the present study suggested cardioprotective activity of Amaranthus cruentus extract.
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