碱基对(3-N-[11C]甲基)spiperone合成影响的比较研究

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes Pub Date : 1992-12-01 DOI:10.1016/0883-2889(92)90185-H

Claudio Pascali, Ren Iwata , Tatsuo Ido

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引用次数: 4

摘要

本文报道了一系列(3-N-[11C]甲基)spiperone在几种基本条件下通过包含“在线”甲基化的自动化系统的制备。观察到放射线化学产率受含水量的强烈影响。反应温度为80℃，反应时间为5 min，考察了这两个参数对甲醇四丁基氢氧化铵合成放化学产率的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Comparative study on the influence of bases on (3-N-[11C]methyl)spiperone synthesis

A series of preparations of (3- $N- [^{11} C]methyl)spiperone$ in several basis conditions by means of an automated system incorporating an “on-line” methylation is reported. The radiochemical yield was observed to be strongly affected by the water content. For all the preparations the reaction temperature was 80°C and the reaction time 5 min. The influence of these two parameters on the radiochemical yield for the synthesis utilizing methanolic tetrabutylammonium hydroxide has been briefly examined.

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International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes

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