人脾后皮质损伤:两例及文献复习

Lin Song, P. Constanthin, N. Lin, Yong-jie Tian, L. An
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引用次数: 1

摘要

背景:人脾后皮层(RSC)是顶叶的皮质区域,位于胼胝体脾的正后方。虽然最近在动物模型中的基础研究表明RSC在定向中起着非常重要的作用,但文献中报道的RSC病变的人类病例相对较少。此外,这些少数案例表明,除了上述这种皮质结构在地形取向中的作用外,在记忆处理和语言等高阶认知功能中还有其他补充作用的潜力。病例介绍:在这篇文章中,我们报告了两例明显无症状的RSC广泛肿瘤病变的病例,这些病例发生在年龄小于35岁的健康患者中。我们报告他们的手术治疗和出院情况。在整个随访期间,患者从未报告任何地形定位或语言问题,这与先前报道的病例相比是显着的。讨论和结论:我们随后讨论了关于人脑RSC病变的现有临床文献,以及在看似相似的放射实体的病例之间报告的症状多样性或缺乏症状的可能原因。我们的病例表明,对RSC及其病变的了解仍然很少,需要从根本上和临床上进一步研究。
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Injury to the human retrosplenial cortex: Two cases and a review of the literature
Background: The human retrosplenial cortex (RSC) is the cortical region of the parietal lobe that lies directly behind the splenium of the corpus callosum. While recent fundamental research in animal models has suggested a very important role for the RSC in orientation, relatively few human cases of lesion to the RSC have been reported in the literature. Furthermore, those few cases have pointed at, in addition to the aforementioned role of this cortical structure in topographical orientation, a potential for other supplementary roles in higher-order cognitive functions such as memory processing and language. Cases presentation: In this article, we report two remarkably asymptomatic cases of extensive oncological lesions to the RSC in otherwise healthy patients younger than 35 years old. We report their surgical treatments and their release from our hospital. During the entire follow-up, patients never reported any issue with topographical orientation or language, which is remarkable compared to cases previously reported. Discussion and conclusions: We then discuss the available clinical literature about RSC lesions in human brain and the possible reasons for such a diversity of reported symptoms, or lack thereof, between cases for a seemingly similar radiological entity. Our cases reveal that understanding of the RSC and its lesions remain scarce and needs to be further investigated, both fundamentally and clinically.
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