几种含有维生素B的剂型及其在治疗中的应用

Ö. Çoban
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引用次数: 0

摘要

维生素B在DNA的合成和维持组织的正常功能中起着关键作用。因此,它的缺乏可能导致精神问题,如抑郁症、精神分裂症、痴呆,以及全身问题,如巨幼细胞性贫血和周围神经病变。维生素B缺乏可能是基于营养,以及一些药物如二甲双胍和奥美拉唑的使用抑制了B族维生素的吸收,这可能导致缺乏。由于B族维生素是水溶性的,它不能储存在体内。因此,它应该与食物一起连续服用。然而,如果从食物中摄取的维生素B不足以满足身体的需要,就应该通过药物或从外部补充维生素B。研究表明,食物补充剂中维生素B的吸收率比食物中高50%。由于它在某些肿瘤细胞中过表达,也可以作为肿瘤治疗的靶向药物。由于维生素B的这些特性,人们正在开发各种剂型。本章将介绍含维生素b的剂型、生产工艺及其在治疗中的应用。
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Several Dosage Forms Containing Vitamin B and Their Use in Therapy
Vitamin B plays a critical role in the synthesis of DNA and maintaining the normal functioning of tissues. Therefore, its deficiency may lead to mental problems such as depression, schizophrenia, dementia, and systemic problems such as megaloblastic anemia and peripheral neuropathy. Vitamin B deficiency may be based on nutrition, as well as the use of some drugs such as metformin and omeprazole suppress the absorption of B vitamins, which may lead to deficiency. Since B vitamin is water soluble, it cannot be stored in the body. For this reason, it should be taken continuously with food. However, in cases where the vitamin B taken with food is not sufficient for the body, it should be reinforced with drugs or dietary supplements from outside. Studies have shown that the absorption of Vitamin B is 50% higher in food supplements than in foods. It can also be used as a targeting agent in tumor therapy, due to its overexpression in some tumor cells. Due to these properties of Vitamin B, various dosage forms are being developed. In this chapter, vitamin B-containing dosage forms, their production techniques, and their use in therapy will be mentioned.
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