J. Hamuro , M. Röllinghoff , H. Wagner , M. Seitz , W. Grimm , D. Gemsa
{"title":"T细胞佐剂香菇多糖诱导的腹膜细胞前列腺素释放抑制","authors":"J. Hamuro , M. Röllinghoff , H. Wagner , M. Seitz , W. Grimm , D. Gemsa","doi":"10.1016/S0340-904X(79)80007-X","DOIUrl":null,"url":null,"abstract":"<div><p>PGE and PGF release from peritoneal exudate cells was studied in mice after injection with two ß (1–3) glucans, the antitumor active lentinan and the inactive pachyman. 4 days after injection of both polysaccharides, the spontaneous and phagocytosis-induced PGE and PGF release was markedly suppressed. However, only the immunopotentiator lentinan induced peritoneal exudate cells which exhibited a longer lasting diminished PG release. The data suggest that the T cell adjuvant lentinan may potentiate cellular immune responses by reducing synthesis of immune suppressive prostaglandins from peritoneal exudate cells.</p></div>","PeriodicalId":101288,"journal":{"name":"Zeitschrift für Immunit?tsforschung: Immunobiology","volume":"155 3","pages":"Pages 248-254"},"PeriodicalIF":0.0000,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0340-904X(79)80007-X","citationCount":"11","resultStr":"{\"title\":\"Depressed Prostaglandin Release from Peritoneal Cells Induced by a T Cell Adjuvant, Lentinan\",\"authors\":\"J. Hamuro , M. Röllinghoff , H. Wagner , M. Seitz , W. Grimm , D. Gemsa\",\"doi\":\"10.1016/S0340-904X(79)80007-X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>PGE and PGF release from peritoneal exudate cells was studied in mice after injection with two ß (1–3) glucans, the antitumor active lentinan and the inactive pachyman. 4 days after injection of both polysaccharides, the spontaneous and phagocytosis-induced PGE and PGF release was markedly suppressed. However, only the immunopotentiator lentinan induced peritoneal exudate cells which exhibited a longer lasting diminished PG release. The data suggest that the T cell adjuvant lentinan may potentiate cellular immune responses by reducing synthesis of immune suppressive prostaglandins from peritoneal exudate cells.</p></div>\",\"PeriodicalId\":101288,\"journal\":{\"name\":\"Zeitschrift für Immunit?tsforschung: Immunobiology\",\"volume\":\"155 3\",\"pages\":\"Pages 248-254\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1979-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0340-904X(79)80007-X\",\"citationCount\":\"11\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zeitschrift für Immunit?tsforschung: Immunobiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0340904X7980007X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift für Immunit?tsforschung: Immunobiology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0340904X7980007X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Depressed Prostaglandin Release from Peritoneal Cells Induced by a T Cell Adjuvant, Lentinan
PGE and PGF release from peritoneal exudate cells was studied in mice after injection with two ß (1–3) glucans, the antitumor active lentinan and the inactive pachyman. 4 days after injection of both polysaccharides, the spontaneous and phagocytosis-induced PGE and PGF release was markedly suppressed. However, only the immunopotentiator lentinan induced peritoneal exudate cells which exhibited a longer lasting diminished PG release. The data suggest that the T cell adjuvant lentinan may potentiate cellular immune responses by reducing synthesis of immune suppressive prostaglandins from peritoneal exudate cells.
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