{"title":"橄榄油修饰的泛醌(Q10)纳米乳在大鼠皮肤中的渗透作用","authors":"F. Deapsari, T. Erawati, Widji Soeratri","doi":"10.25258/IJPCR.V9I2.8300","DOIUrl":null,"url":null,"abstract":"Ubiquinon (Q10) is an endogenous antioxidant. It is lipophilic and practically insoluble in water. To improve its solubility and penetration, it was formulated into O/W nanoemulsion. The resulting Q10 nanoemulsion was then physically characterized for its droplet size, morphology, and viscosity. In addition, it was conducted a penetration test of Q10 in nanoemulsion delivery system compared to Q10 in emulsion using male Wistar rats. From the characterization results, it was found that the droplet size of Q10 nanoemulsion (70.07 ± 12.42 nm) Q10 in emulsion (20.429 μm/h).","PeriodicalId":19889,"journal":{"name":"Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2017-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":"{\"title\":\"Penetration of Ubiquinone (Q10) Nanoemulsion Using Olive Oil Through Rat Skin\",\"authors\":\"F. Deapsari, T. Erawati, Widji Soeratri\",\"doi\":\"10.25258/IJPCR.V9I2.8300\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Ubiquinon (Q10) is an endogenous antioxidant. It is lipophilic and practically insoluble in water. To improve its solubility and penetration, it was formulated into O/W nanoemulsion. The resulting Q10 nanoemulsion was then physically characterized for its droplet size, morphology, and viscosity. In addition, it was conducted a penetration test of Q10 in nanoemulsion delivery system compared to Q10 in emulsion using male Wistar rats. From the characterization results, it was found that the droplet size of Q10 nanoemulsion (70.07 ± 12.42 nm) Q10 in emulsion (20.429 μm/h).\",\"PeriodicalId\":19889,\"journal\":{\"name\":\"Pharmaceutical and Clinical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-02-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmaceutical and Clinical Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.25258/IJPCR.V9I2.8300\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmaceutical and Clinical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.25258/IJPCR.V9I2.8300","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Penetration of Ubiquinone (Q10) Nanoemulsion Using Olive Oil Through Rat Skin
Ubiquinon (Q10) is an endogenous antioxidant. It is lipophilic and practically insoluble in water. To improve its solubility and penetration, it was formulated into O/W nanoemulsion. The resulting Q10 nanoemulsion was then physically characterized for its droplet size, morphology, and viscosity. In addition, it was conducted a penetration test of Q10 in nanoemulsion delivery system compared to Q10 in emulsion using male Wistar rats. From the characterization results, it was found that the droplet size of Q10 nanoemulsion (70.07 ± 12.42 nm) Q10 in emulsion (20.429 μm/h).
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