Z. Nadi, M. Bayat, Hadi Karami, M. Parastesh, P. Bayat
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引用次数: 3
摘要
脂联素及其受体在男性生殖系统中表达，在调节男性性激素和生育能力中起作用。采用链脲唑素-烟酰胺(STZ-NA i.p)诱导大鼠糖尿病，训练结束后采用real - time PCR检测大鼠睾丸脂联素基因及其受体的表达，并测定血清FSH、LH和睾酮水平。STZ-NA显著提高糖尿病大鼠空腹血糖、睾丸脂联素AdipoR1基因表达。糖尿病组血清睾酮和黄体生成素水平显著降低。抵抗和耐力训练降低糖尿病大鼠血糖、脂联素和AdipoR1基因，提高血清睾酮和LH水平。总的来说，我们的数据表明，训练通过增加2型糖尿病大鼠的血清睾酮和LH水平来改善脂联素和AdipoR1基因的表达。
Effect of Exercise Training on Gene Expression of Adiponectin and its Receptors in Testicles and Sex Hormones in Diabetic Rats
Adiponectin and its receptors are expressed in the male reproductive system, which play a role in regulating male sex hormones and fertility. Diabetes was induced by Streptozotocin-Nicotinamide (STZ-NA i.p) in rats and after performing the trainings, adiponectin gene expression and its receptors in the testis were evaluated using real time PCR, and blood serum was then used in order to assess FSH, LH and testosterone. The STZ-NA significantly increased the fasting blood glucose, gene expression of adiponectin AdipoR1 in the testicles of diabetic rats. A significant reduction in serum testosterone and LH levels were observed in the diabetic group. Resistance and endurance training decreased blood glucose, adiponectin and AdipoR1 gene, and also increased the serum testosterone and LH levels in diabetic rats. Overall, our data suggest the role played by training in improve expression of adiponectin and AdipoR1 gene by increasing the serum testosterone and LH levels in type 2 diabetic rats.
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