ONJ (MRONJ)更新2021 -与双膦酸盐和其他药物相关的颌骨骨坏死-预防,诊断,药物警戒,治疗:2021网络事件

V. Fusco, G. Campisi, P. Carcieri, F. Fagioli, O. Bertetto, M. Mignogna, A. Bedogni
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摘要

2021年5月8日和9日,意大利医师、牙医和口腔护理专家、学生、护士、心理学家、口腔卫生专家和其他专业人士组织了一次在线会议,讨论有关药物相关性颌骨骨坏死(MRONJ)的争议性问题。第一部分评估了意大利口腔病理与医学学会(SIPMO)和颌面外科学会(SICMF)于2020年发布的意大利建议与其他国际实践指南或文件之间的差异。第一次圆桌会议收集了专家对MRONJ定义和分期系统的意见。另一个圆桌会议专门讨论开处方的医生(肿瘤学家、血液学家、风湿病学家和其他治疗骨质疏松症的医生)的意见。教育会议说明了之前(2013年)和最近(2020年)意大利建议之间的主要区别。一个很大的空间专门用于展示意大利各中心的科学贡献,分为具体的会议(流行病学;系列;特殊个案报告;预防经验;MRONJ治疗)。结论:在一个创新的网络会议上,会谈和科学报告强调了充分的骨成像研究对MRONJ病例的定义和分期的重要性,手术在疾病治疗中的作用,以及口腔卫生在预防中的价值。
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ONJ (MRONJ) Update 2021—Osteonecrosis of Jaw Related to Bisphosphonates and Other Drugs—Prevention, Diagnosis, Pharmacovigilance, Treatment: A 2021 Web Event
On the 8th and 9th of May 2021, an online conference was organized to connect Italian physicians, dentists and oral care specialists, students, nurses, psychologists, dental hygiene experts, and other professionals to discuss controversial issues about Medication-Related Osteonecrosis of Jaw (MRONJ). The first section evaluated differences between Italian recommendations, released on 2020 by Italian Societies of Oral Pathology and Medicine (SIPMO) and Maxillofacial Surgery (SICMF), and other international practice guidelines or documents. A first round table gathered expert opinions about MRONJ definitions and staging systems. Another round table was dedicated to opinion of drug prescribers (oncologists, hematologists, rheumatologists, and other physicians treating osteoporosis). Educational sessions illustrated the main differences between previous (2013) and more recent (2020) Italian recommendations. A large space was dedicated to the presentation of scientific contributions from centers in Italy, divided in specific sessions (epidemiology; case series; special case reports; prevention experiences; MRONJ treatment). Conclusions: in an innovative web conference, talks and scientific reports underlined importance of adequate imaging study of bone in definition and staging of MRONJ cases, the role of surgery in treatment of the disease, and the value of oral hygiene in the prevention.
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