COVID - 19感染后塌陷性肾小球病变;让我们来回顾一下最近的数据

Leila Alem, Maryam Farahmandsadr, Azadeh Khayyat, Mohammad Ali Esmaeil pour, H. Nasri
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引用次数: 0

摘要

塌陷性肾小球病变已被描述为COVID-19患者最常见的形态学特征,表现为快速进展性肾功能衰竭和大量蛋白尿。这种情况也被称为covid -19相关肾病,预后较差。在covid -19相关的塌陷性肾小球病中,免疫功能障碍介导的对具有APOL1风险等位基因的非洲足细胞的“第二次打击”被提出。然而,还需要进一步的研究来阐明肾小球病变的这一方面。
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Collapsing glomerulopathy following COVID 19 infection; a mini-review to the recent data
Collapsing glomerulopathy has been delineated as the most common morphological feature in COVID-19 individuals presenting with rapidly progressive renal failure and massive proteinuria. This condition, also known as COVID-19-associated nephropathy, has a poor prognosis. In COVID-19-related collapsing glomerulopathy, an immune dysfunction-mediated "second hit" to podocytes of African origin with APOL1 risk alleles was suggested. However, further research is still required to clarify this aspect of glomerulopathy.
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